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Chemerin blood levels are associated with cross-sectional areas of different compartments of adipose tissue at L5 level

Introduction: Increasing obesity prevalence is of great importance since it is associated with low-grade chronic inflammation. Adypocytes which constitute adipose tissue, among other cells, produce a large number of adipocytokines which are responsible for immunometabolic modulation. Chemerin is a multifunctional protein which primarily acts as a chemotactic cytokine. Chemerin is associated with early stages of low-grade chronic inflammation of adipose tissue possibly through regrutation of immune cells to the adipose tissue, angiogenesis, osteoblastogenesis etc. We aim to investigate the relationship between chemerin blood levels and abdominal region adipose tissues. Methods: We included 60 volunteers in the study ; all participants underwent magnetic resonance (MR) of abdominal region using 2D FLSAH sequence for optimal detection of adipose tissue. MR data was analyzed using open source ImageJ program in order to obtain the adipose tissue surface area. Blood samples were taken from all participants, chemerin serum levels were determined with commercial ELISA kit. Results: Average participant had BMI of 24.5±4.7 and was 20 [20–30.75] years old. The average area of adipose tissue at L5 level was 281±119 cm2, subcutaneous adipose tissue 215±91 cm2 and visceral adipose tissue 65±38 cm2. Chemerin positively correlated with overall adipose tissue (r=0.721, p<0.001), subcutaneous (r=0.694, p<0.001) and visceral adipose tissue (r=0.588, p<0.001). After age and gender adjustment, over-all adipose tissue was the most important predictor of chemerin levels(R2=0.749, p<0.001, β=0.27). Conclusion: Chemerin blood levels had a strong and medium positive correlation with different compartments of adipose tissue. Visceral and subcutaneous adipose tissue might contribute equally to the chemerim blood levels.

obesity; chemerin; abdominal adipose tissue

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