engleski

Continuum model of gene expression by small non-coding RNAs and protein Argonaute.

In this poster we present mathematical model of gene expression based on coupled system of partial differential equations that describes complex evolution of mRNA and sRNA concentrations in a small part of tissue. Model of the interaction between one mRNA and different types of non-coding sRNAs in biological cells have been recently described by system the of coupled reaction- diffusion equations. In order to model interaction between mRNAs and sRNAs more accurately, it is not sufficient to only focus on their concentrations in the cell or tissue. Studies have shown that members of the Argonaute (Ago) protein family have essential role in RNA silencing process, as one of the key components of RNA-induced silencing complex (RISC). sRNA alone is not enough to suppress the expression of specific genes. In order for suppression to occur, it is necessary that sRNA interacts with multiprotein complex RISC, more specifically with its essential component - Ago protein. We propose mathematical model that takes in to account the importance of Ago protein, allowing us to model evolution of mRNA, sRNA concentrations on the tissue level. We also present computational results.

pde; non-coding RNA; Argonaute

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