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Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system (CROSBI ID 630609)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Fuller, Heidi R. ; Slade, Robert ; Jovanov- Milošević, Nataša ; Babić, Mirjana ; Sedmak, Goran ; Šimić, Goran ; Fuszard, Matthew A. ; Shirran, Sally L. ; Botting, Catherine H. ; Gates, Monte A. Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system // Book of abstracts of the FENS Featured Regional Meeting 2015. 2015. str. 52-52

Podaci o odgovornosti

Fuller, Heidi R. ; Slade, Robert ; Jovanov- Milošević, Nataša ; Babić, Mirjana ; Sedmak, Goran ; Šimić, Goran ; Fuszard, Matthew A. ; Shirran, Sally L. ; Botting, Catherine H. ; Gates, Monte A.

engleski

Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system

The mammalian corticospinal tract (CST) is the longest efferent axonal projection in the central nervous system, originating from upper motor neurons in layer V of the cortex. Little, though, is known about the proteins that are important to the growth of corticospinal neurons down the spinal cord. This is unfortunate because regeneration of the CST is of great therapeutic importance. There are an estimated 6, 500 cases of spinal cord injury (SCI) per year in Western Europe, and between 100, 000-200, 000 incidences worldwide. One hope is that by identifying key intracellular and extracellular proteins involved in the development and growth of the corticospinal system, the regeneration of the mature CST might be enhanced by manipulating these developmental constituents. The aim of this study, therefore, was to conduct a comprehensive temporal and spatial quantitative proteomics analysis of the rat CST during its formation.

Corticospinal tract; stathmin; developing brain

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Podaci o prilogu

52-52.

2015.

objavljeno

Podaci o matičnoj publikaciji

Book of abstracts of the FENS Featured Regional Meeting 2015

Podaci o skupu

FENS Featured Regional Meeting 2015

poster

07.10.2015-10.10.2015

Solun, Grčka

Povezanost rada

Temeljne medicinske znanosti