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Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system


Fuller, Heidi R.; Slade, Robert; Jovanov- Milošević, Nataša; Babić, Mirjana; Sedmak, Goran; Šimić, Goran; Fuszard, Matthew A.; Shirran, Sally L.; Botting, Catherine H.; Gates, Monte A.
Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system // Book of abstracts of the FENS Featured Regional Meeting 2015
Thessaloniki, Grčka, 2015. str. 52-52 (poster, međunarodna recenzija, sažetak, ostalo)


Naslov
Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system

Autori
Fuller, Heidi R. ; Slade, Robert ; Jovanov- Milošević, Nataša ; Babić, Mirjana ; Sedmak, Goran ; Šimić, Goran ; Fuszard, Matthew A. ; Shirran, Sally L. ; Botting, Catherine H. ; Gates, Monte A.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of abstracts of the FENS Featured Regional Meeting 2015 / - , 2015, 52-52

Skup
FENS Featured Regional Meeting 2015

Mjesto i datum
Thessaloniki, Grčka, 7-10.10.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Corticospinal tract; stathmin; developing brain

Sažetak
The mammalian corticospinal tract (CST) is the longest efferent axonal projection in the central nervous system, originating from upper motor neurons in layer V of the cortex. Little, though, is known about the proteins that are important to the growth of corticospinal neurons down the spinal cord. This is unfortunate because regeneration of the CST is of great therapeutic importance. There are an estimated 6, 500 cases of spinal cord injury (SCI) per year in Western Europe, and between 100, 000-200, 000 incidences worldwide. One hope is that by identifying key intracellular and extracellular proteins involved in the development and growth of the corticospinal system, the regeneration of the mature CST might be enhanced by manipulating these developmental constituents. The aim of this study, therefore, was to conduct a comprehensive temporal and spatial quantitative proteomics analysis of the rat CST during its formation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
IP-2014-09-9730

Ustanove
Medicinski fakultet, Zagreb