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The effect of ASS234 on tau phosphorylation in vitro


Babić, Mirjana; Jazvinšćak Jembrek, Maja; Knezović, Ana; Hof, Patrick R.; Šimić, Goran
The effect of ASS234 on tau phosphorylation in vitro // Book of abstracts of the 5th Mediterranean Neuroscience Society Meeting
Santa Margherita di Pula - Sardinia, Italija, 2015. str. 365-365 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
The effect of ASS234 on tau phosphorylation in vitro

Autori
Babić, Mirjana ; Jazvinšćak Jembrek, Maja ; Knezović, Ana ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the 5th Mediterranean Neuroscience Society Meeting / - , 2015, 365-365

Skup
5th Mediterranean Neuroscience Society Meeting

Mjesto i datum
Santa Margherita di Pula - Sardinia, Italija, 12-15.06.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ASS234; SH-SY5Y cells; Alzheimer’s disease; tau phosphorylation

Sažetak
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly (affecting over 30 million people worldwide). AD is characterized by the presence in the brain of plaques composed of amyloid beta peptide and of neurofibrillary tangles made of hyperphosphorylated protein tau. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules (MT), allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of oligomers leads to the formation of paired helical filaments, the primary constituent of neurofibrillary tangles (NFT). A number of neuroprotective strategies are being suggested to counter tau hyperhosphorylation and to reduce tau aggregates: 1) MT-stabilizing agents, 2) modulation of tau phosphorylation, 3) tau aggregation inhibitors, 4) targeting extracellular tau oligomers, 5) targeting tau clearance, and 6) targeting tau proteolysis. A multipotent, blood-brain barrier-permeable compound ASS234, has already been shown to inhibit Aβ aggregation, possesses antioxidant properties, and protects from Aβ-induced apoptosis in vitro (Bolea et al., Curr. Alzheimer Res., 2013), but its properties in regard to tau phosphorylation and aggregation have not been yet studied. The goal of this study was to assess the influence of ASS234 on tau phosphorylation in SH-SY5Y cells. Preliminary results of the study will be presented and discussed during the poster session.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
IP-2014-09-9730

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb