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izvor podataka: crosbi

Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid (CROSBI ID 630605)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid // Journal of trace elements in medicine and biology / Jurasović, Jasna ; Aschner, Michael (ur.). 2015. str. 7-7

Podaci o odgovornosti

Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran

engleski

Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid

The homeostasis of macro and microelements is altered in the brain of patients suffering from Alzheimer’s disease (AD). In this study we analysed 24 macro and microelements in cerebrospinal fluid (CSF) and correlated its concentration with AD protein biomarkers (Aβ1- 42, t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1) in CSF of 63 patients with AD, 31 with mild cognitive impairment (MCI), and 11 healthy controls (HC). A significantly negative correlation was found between Aβ1-42 and Co, while significantly positive correlations were obtained between t-tau and Li, As, Se, Sr ; p- tau181 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Mo, Tl, Hg ; p-tau199 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Cu, As, Se, Sr, Mo, Cd, Ba, Tl, Hg ; p-tau231 and Li, B, Na, Mg, S, K, Cr, Fe, Co, Mn, Ni, Cu, Zn, Se, Sr, Mo, Tl, Hg ; VILIP-1 and Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Hg. Although possible explanation of altered levels of elements in AD brain will await identification of their environmental sources or detection of their release from brain tissue due to cell death, these results suggest CSF element analysis potential as marker of AD neurodegenerative process.

Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements

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Podaci o prilogu

7-7.

2015.

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objavljeno

Podaci o matičnoj publikaciji

Journal of trace elements in medicine and biology

Jurasović, Jasna ; Aschner, Michael

Elsevier

0946-672X

Podaci o skupu

Recent Advances in Trace Element Research in Health and Disease

poster

18.10.2015-22.10.2015

Srebreno, Hrvatska

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost