Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid (CROSBI ID 630605)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran
engleski
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid
The homeostasis of macro and microelements is altered in the brain of patients suffering from Alzheimer’s disease (AD). In this study we analysed 24 macro and microelements in cerebrospinal fluid (CSF) and correlated its concentration with AD protein biomarkers (Aβ1- 42, t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1) in CSF of 63 patients with AD, 31 with mild cognitive impairment (MCI), and 11 healthy controls (HC). A significantly negative correlation was found between Aβ1-42 and Co, while significantly positive correlations were obtained between t-tau and Li, As, Se, Sr ; p- tau181 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Mo, Tl, Hg ; p-tau199 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Cu, As, Se, Sr, Mo, Cd, Ba, Tl, Hg ; p-tau231 and Li, B, Na, Mg, S, K, Cr, Fe, Co, Mn, Ni, Cu, Zn, Se, Sr, Mo, Tl, Hg ; VILIP-1 and Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Hg. Although possible explanation of altered levels of elements in AD brain will await identification of their environmental sources or detection of their release from brain tissue due to cell death, these results suggest CSF element analysis potential as marker of AD neurodegenerative process.
Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements
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Podaci o prilogu
7-7.
2015.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Journal of trace elements in medicine and biology
Jurasović, Jasna ; Aschner, Michael
Elsevier
0946-672X
Podaci o skupu
Recent Advances in Trace Element Research in Health and Disease
poster
18.10.2015-22.10.2015
Srebreno, Hrvatska