Napredna pretraga

Pregled bibliografske jedinice broj: 790225

Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid


Babić Leko, Mirjana; Borovečki, Fran; Jurasović, Jasna; Orct, Tatjana; Hof, Patrick R.; Šimić, Goran
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid // JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY / Jurasović, Jasna ; Aschner, Michael (ur.).
Srebreno, Hrvatska: Elsevier GmbH, 2015. str. 7-7 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid

Autori
Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY / Jurasović, Jasna ; Aschner, Michael - : Elsevier GmbH, 2015, 7-7

Skup
Recent Advances in Trace Element Research in Health and Disease

Mjesto i datum
Srebreno, Hrvatska, 18-22.10.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements

Sažetak
The homeostasis of macro and microelements is altered in the brain of patients suffering from Alzheimer’s disease (AD). In this study we analysed 24 macro and microelements in cerebrospinal fluid (CSF) and correlated its concentration with AD protein biomarkers (Aβ1- 42, t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1) in CSF of 63 patients with AD, 31 with mild cognitive impairment (MCI), and 11 healthy controls (HC). A significantly negative correlation was found between Aβ1-42 and Co, while significantly positive correlations were obtained between t-tau and Li, As, Se, Sr ; p- tau181 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Mo, Tl, Hg ; p-tau199 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Cu, As, Se, Sr, Mo, Cd, Ba, Tl, Hg ; p-tau231 and Li, B, Na, Mg, S, K, Cr, Fe, Co, Mn, Ni, Cu, Zn, Se, Sr, Mo, Tl, Hg ; VILIP-1 and Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Hg. Although possible explanation of altered levels of elements in AD brain will await identification of their environmental sources or detection of their release from brain tissue due to cell death, these results suggest CSF element analysis potential as marker of AD neurodegenerative process.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
IP-2014-09-9730

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE