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Pregled bibliografske jedinice broj: 790223

Levels of cerebrospinal fluid macro and microelements in mild cognitive impairment patients with and without pathological levels of six Alzheimer’s disease protein biomarkers


Babić Leko, Mirjana; Borovečki, Fran; Jurasović, Jasna; Orct, Tatjana; Hof, Patrick R.; Šimić, Goran
Levels of cerebrospinal fluid macro and microelements in mild cognitive impairment patients with and without pathological levels of six Alzheimer’s disease protein biomarkers // Book of abstracts of the 5th Croatian Neuroscience Congress
Split, Hrvatska, 2015. str. 71-72 (poster, međunarodna recenzija, sažetak, ostalo)


Naslov
Levels of cerebrospinal fluid macro and microelements in mild cognitive impairment patients with and without pathological levels of six Alzheimer’s disease protein biomarkers

Autori
Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of abstracts of the 5th Croatian Neuroscience Congress / - , 2015, 71-72

Skup
5th Croatian Neuroscience Congress

Mjesto i datum
Split, Hrvatska, 17-19.09.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements

Sažetak
Objective: Alzheimer's disease (AD) is the major primary cause of dementia. Mild cognitive impairment (MCI) is a syndrome characterized by cognitive impairment without dementia. About 10% MCI patients have an initial stage of AD. There is an urgent need for detection of novel CSF biomarkers that would improve early diagnosis of AD. As homeostasis of macro and microelements is disturbed in the AD brain, measurement of macro and microelements’ levels in the cerebrospinal fluid (CSF) has a diagnostic potential in identification of MCI patients who will progress to AD. The main goal of this study was to differentiate two groups of MCI patients (with and without pathological levels of AD protein biomarkers, altogether 31 MCI patients) by using concentrations of 24 macro and microelements measured in CSF (Li, B, Na, Mg, Al, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Pb, and Hg). Methods: Six AD protein biomarkers (Aβ1-42, t- tau, p-tau181, p-tau199, p-tau231 and VILIP-1) were measured using ELISA, while CSF macro and microelements were measured using inductively coupled plasma mass spectroscopy (ICP-MS). Results: Levels of S, Co, Mo, and Tl were significantly increased in the MCI group with pathological Aβ1-42 levels, while levels of K, Cr, Fe, Cu, As, Se, and Hg were significantly increased in the MCI group with pathological p- tau181 levels. Significant increase in Ca and As levels was found in the MCI group with pathological p-tau199 levels, while the MCI group with pathological p-tau231 levels had increased concentrations of Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, and Hg. The MCI group with pathological VILIP-1 levels had significantly higher levels of Na, Mg, S, K, Ca, Cr, Fe, Mn, Cu, As, Se, Sr, Ba, and Hg. Conclusions: Despite being preliminary and obtained from a relatively small cohort of MCI patients, these results indicate that macro and microelements can be potentially used as diagnostic markers of disease progression. The most probable CSF metals biomarkers are Hg, K, Cr, Fe, S, Cu, As and Se, since their levels were increased in MCI groups with even three pathological protein biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
IP-2014-09-9730

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb