Napredna pretraga

Pregled bibliografske jedinice broj: 790222

Improved early detection of Alzheimer’s disease by combination of event-related potentials and cerebrospinal fluid biomarkers


Babić Leko, Mirjana; Krbot Skorić, Magdalena; Klepac, Nataša; Palac, Natalia; Langer, Lea; Vogrinc, Željka; Borovečki, Fran; Hof, Patrick R.; Šimić, Goran
Improved early detection of Alzheimer’s disease by combination of event-related potentials and cerebrospinal fluid biomarkers // Book of abstracts of the 5th Croatian Neuroscience Congress
Split, Hrvatska, 2015. str. 70-70 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Improved early detection of Alzheimer’s disease by combination of event-related potentials and cerebrospinal fluid biomarkers

Autori
Babić Leko, Mirjana ; Krbot Skorić, Magdalena ; Klepac, Nataša ; Palac, Natalia ; Langer, Lea ; Vogrinc, Željka ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the 5th Croatian Neuroscience Congress / - , 2015, 70-70

Skup
5th Croatian Neuroscience Congress

Mjesto i datum
Split, Hrvatska, 17-19.09.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Event-related potentials; Alzheimer’s disease; CSF biomarkers

Sažetak
Disease-modifying therapeutics for Alzheimer’s disease (AD) are still not available. Nowadays, the possible cause of clinical trials failures is becoming clearer ; AD therapeutics have been applied to the patients in the final stages of disease, when neurodegeneration is too severe. Cerebrospinal fluid (CSF) and neuroimaging biomarkers proved to be the most promising early biomarkers of AD. However, there is a great need for low-cost, noninvasive biomarkers. Event-related potentials (ERPs) are relatively cheap and noninvasively measured by electroencephalography. In this pilot study we correlatedthe N200 and P300 components of ERPs with six CSF biomarkers (amyloid β1-42, total tau, tau phosphorylated at S199, T181, and T231, and VILIP-1) in AD, mild cognitive impairment (MCI), and patients with other dementias. ERPs were detected by 32 electrodes while patients had to guess the correct tone between three different tones: target, non-target, and intrusive tone. CSF was taken by lumbar puncture in the L3/L4 or L4/L5 intervertebral spaces and levels of the 6 proteins were measured by ELISA. P300 latencies positively correlated with p-tau181 (p=0.041) and p-tau231 (p=0.005) and were higher in the group of patients with Aβ1-42 levels below cut-off (p=0.047) in comparison to the group with Aβ1- 42 levels higher than cut-off. In addition, P300 latencies were higher in the group of patients with p-tau199 levels higher than cut- off (p=0.05). The group of MCI patients with decreased P300 amplitudes had higher p-tau199 levels in comparison to the group with normal P300 amplitudes (p=0.022). RTs were significantly higher in the group of patients with p-tau199 levels higher than cut-off (p=0.017). The same was observed for VILIP-1 (p=0.038). Additionally, RTs correlated with p- tau231 (p=0.001) and p-tau199 (p=0.020), and surprisingly were higher in the both groups of MCI patients with p-tau199 (p=0.017) and VILIP- 1 (p=0.046) levels higher than cut-off. N200 latencies positively correlated with p-tau181 (p=0.005), p-tau199 (p=0.041), VILIP-1 (p=0.003), and total tau (p=0.046). The results of this pilot study indicate correlation of CSF biomarkers with ERP components in AD, MCI, and patients with other dementias. RTs differentiated two groups of MCI patients with pathological and normal levels of p-tau199 or VILIP-1.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )
IP-2014-09-9730

Ustanove
Medicinski fakultet, Zagreb