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Pregled bibliografske jedinice broj: 790221

Combination of event-related potentials and cerebrospinal fluid biomarkers in early diagnosis of Alzheimer’s disease


Babić, Mirjana; Krbot Skorić, Magdalena; Klepac, Nataša; Palac, Natalia; Langer, Lea; Vogrinc, Željka; Borovečki, Fran; Hof, Patrick R.; Šimić, Goran
Combination of event-related potentials and cerebrospinal fluid biomarkers in early diagnosis of Alzheimer’s disease // Neurologia Croatica / Šimić, Goran ; Mimica, Ninoslav (ur.).
Zagreb: Denona d.o.o., 2014. str. 83-84 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Combination of event-related potentials and cerebrospinal fluid biomarkers in early diagnosis of Alzheimer’s disease
(Combination of event-related potentials and cerebrospinal fluid biomarkers in early)

Autori
Babić, Mirjana ; Krbot Skorić, Magdalena ; Klepac, Nataša ; Palac, Natalia ; Langer, Lea ; Vogrinc, Željka ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurologia Croatica / Šimić, Goran ; Mimica, Ninoslav - Zagreb : Denona d.o.o., 2014, 83-84

Skup
Croatian Congress on Alzheimer’s Disease (CROCAD- 14) with International Participation

Mjesto i datum
Brela, Hrvatska, 01-04.10.2014.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Event-related potentials ; Alzheimer’s disease ; CSF biomarkers

Sažetak
There is a great need for affordable and readily available Alzheimer’s disease (AD) biomarkers that could enable screening of the healthy population. Event-related potentials (ERPs), noninvasively measured by electroencephalography, showed relatively good correlation with neuropsychological testing. In this pilot study we correlated N200 and P300 components of ERPs with six CSF biomarkers (amyloid β1-42, total tau, tau phosphorylated at S199, T181 and T231 and visinin-like protein-1, VILIP-1) in patients with AD (N = 11), mild cognitive impairment (MCI, N = 10), and patients with other primary dementia causes (N = 6). ERPs were detected by 32 electrodes while patients had to guess the correct tone between three different tones: target, non- target, and intrusive tone. CSF was taken by lumbar puncture in the L3/L4 or L4/L5 intervertebral spaces and levels of the 6 proteins were measured by ELISA assay. P300 latencies positively correlated with p-tau181 (P=0.041) and p-tau231 (P=0.005) and were higher in the group of patients with Aβ1-42 levels lower than the cut-off (P=0.047) in comparison to the group with Aβ1-42 levels higher than the cut-off. P300 latencies were higher in the group of patients with p-tau199 levels higher than cut-off (P=0.05). MCI patients with decreased P300 amplitudes had higher p-tau199 levels in comparison to those with normal P300 amplitudes (P=0.022). Reaction times (RTs) were higher in the group with p- tau199 levels higher than the cut-off (P=0.017), and the same was observed for VILIP- 1 (p=0.038). Additionally, RTs positively correlated with p-tau231 (P=0.001) and p-tau199 (P=0.020), and were higher in the both groups of MCI patients with p-tau199 (P=0.017) and VILIP-1 (P=0.046) levels higher than cut-off. N200 latencies positively correlated with p- tau181 (P=0.005), p-tau199 (P=0.041), VILIP-1 (P=0.003), and total tau (P=0.046). This pilot study reveals positive correlations of CSF biomarkers with ERP components, P300 latencies and amplitudes, RTs, and N200 latencies. Moreover, RTs differentiated two groups of MCI patients with pathological and normal levels of p-tau199 and VILIP-1.Therefore, a combination of ERPs and CSF biomarkers in early AD diagnosis deserves further validation in larger patient populations, and regular follow-up of MCI patients at least every other year.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Medicinski fakultet, Zagreb