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Pregled bibliografske jedinice broj: 790106

Response To Hyperoxia Is Associated With Similar Ho-1 Gene Expression Level In Lungs Of Aging Cba Mice Of Both Sexes


Sandra Sobočanec; Željka Mačak Šafranko; Ana Šarić; Marina Korolija; Marijana Popović Hadžija; Tihomir Balog
Response To Hyperoxia Is Associated With Similar Ho-1 Gene Expression Level In Lungs Of Aging Cba Mice Of Both Sexes // Biochemistry and Biophysics Reports, 5 (2016), 55-62 doi:10.1016/j.bbrep.2015.09.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Response To Hyperoxia Is Associated With Similar Ho-1 Gene Expression Level In Lungs Of Aging Cba Mice Of Both Sexes

Autori
Sandra Sobočanec ; Željka Mačak Šafranko ; Ana Šarić ; Marina Korolija ; Marijana Popović Hadžija ; Tihomir Balog

Izvornik
Biochemistry and Biophysics Reports (2405-5808) 5 (2016); 55-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Heme oxygenase; Antioxidant enzyme; Mouse; Sex-related; Oxygen

Sažetak
Beside classical antioxidative enzymes, the response to hyperoxia might be mediated via regulation of other systems, such as heme oxygenase (HO). Ho-1 gene expression is found to be upregulated by hyperoxia in all groups of mice, while HO-1 protein isoform was increased only in 4 months old male mice. In steady-state conditions ho-1 and ho-2 gene expression remained unchanged irrespective of sex or age, which was not the case with protein level of both isoforms. This study suggests that in lungs of CBA mice the response to oxidative stress may be mediated through the interaction of other systems such as heme oxygenase, primarily via upregulation of ho-1 gene expression in both sexes. Contrary to our previous study in liver of hyperoxia treated mice, current results might imply that at conventional oxygen conditions lungs of female mice with the emphasis on aging females, are better prepared for oxidative stress conditions through the increase of HO-activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Scopus


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