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Pregled bibliografske jedinice broj: 789014

Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging


Babić-Stojić, Branka; Jokanović, Vukoman; Milivojević, Dušan; Požek, Miroslav; Jagličić, Zvonko; Makovec, Darko; Arsikin, Katarina; Paunović, Verica
Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging // Journal of magnetism and magnetic materials, 403 (2016), 118-126 doi:10.1016/j.jmmm.2015.11.075 (međunarodna recenzija, članak, znanstveni)


Naslov
Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging

Autori
Babić-Stojić, Branka ; Jokanović, Vukoman ; Milivojević, Dušan ; Požek, Miroslav ; Jagličić, Zvonko ; Makovec, Darko ; Arsikin, Katarina ; Paunović, Verica

Izvornik
Journal of magnetism and magnetic materials (0304-8853) 403 (2016); 118-126

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gadolinium oxide ; Magnetic nanoparticles ; Relaxivity ; Magnetic resonance imaging ; Contrast agents ; Toxicity

Sažetak
Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystalviolet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5T, estimated to be r1(Gd2O3)=9.6 s-1 mM-1 in the Gd concentration range 0.1–30 mM and r2(Gd2O3)=17.7s-1 mM-1 in the lower concentration range 0.1–0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1s-1 mM-1 and r2(Gd-DTPA)=5.1s-1 mM-1. The ratio of the two relaxivities for Gd2O3 nanoparticles r2/r1=1.8 is suitable for T1-weighted imaging. Good MRI signal intensities of the water diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2–0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Ustanove
Prirodoslovno-matematički fakultet, Zagreb

Autor s matičnim brojem:
Miroslav Požek, (160426)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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