Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation (CROSBI ID 222906)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Artigas, M.S. ; Wain, L.V. ; Miller, S. ; ... ; Polašek, Ozren ; ... ; Kolčić, Ivana ; ... ; Zemunik, Tatijana ; ... ; Tobin, M.D.
engleski
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38, 199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54, 550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
spirometry; lung function; genetics
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita