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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation


Artigas, M.S.; Wain, L.V.; Miller, S.; ...; Polašek, Ozren; ...; Kolčić, Ivana; ...; Zemunik, Tatijana; ...; Tobin, M.D.
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation // Nature Communications, 6 (2015), 8658-1 doi:10.1038/ncomms9658 (međunarodna recenzija, članak, znanstveni)


Naslov
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Autori
Artigas, M.S. ; Wain, L.V. ; Miller, S. ; ... ; Polašek, Ozren ; ... ; Kolčić, Ivana ; ... ; Zemunik, Tatijana ; ... ; Tobin, M.D.

Izvornik
Nature Communications (2041-1723) 6 (2015); 8658-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Spirometry; lung function; genetics

Sažetak
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38, 199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54, 550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Citiraj ovu publikaciju

Artigas, M.S.; Wain, L.V.; Miller, S.; ...; Polašek, Ozren; ...; Kolčić, Ivana; ...; Zemunik, Tatijana; ...; Tobin, M.D.
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation // Nature Communications, 6 (2015), 8658-1 doi:10.1038/ncomms9658 (međunarodna recenzija, članak, znanstveni)
Artigas, M., Wain, L., Miller, S., ..., Polašek, O., ..., Kolčić, I., ..., Zemunik, T., ... & Tobin, M. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 8658-1 doi:10.1038/ncomms9658.
@article{article, year = {2015}, pages = {8658-1-8658-}, DOI = {10.1038/ncomms9658}, keywords = {spirometry, lung function, genetics}, journal = {Nature Communications}, doi = {10.1038/ncomms9658}, volume = {6}, issn = {2041-1723}, title = {Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation}, keyword = {spirometry, lung function, genetics} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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