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Utjecaj glukoze i adipokina na porođajnu težinu kod trudnica sa šećernom bolesti tipa 1


Berberović, Edina; Ivanišević, Marina; Horvatiček, Marina; Kralik-Oguić, Saša; Đelmiš, Josip.
Utjecaj glukoze i adipokina na porođajnu težinu kod trudnica sa šećernom bolesti tipa 1 // Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 23 (2014), 4; 116-120 (međunarodna recenzija, članak, znanstveni)


Naslov
Utjecaj glukoze i adipokina na porođajnu težinu kod trudnica sa šećernom bolesti tipa 1
(The relation of glucose and adipokines to birthweight in type 1 diabetic pregnancy)

Autori
Berberović, Edina ; Ivanišević, Marina ; Horvatiček, Marina ; Kralik-Oguić, Saša ; Đelmiš, Josip.

Izvornik
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics (1330-0091) 23 (2014), 4; 116-120

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adiponectin; Birthweight; Leptin; Pregnancy; Type 1 diabetes

Sažetak
Aims. The aim of this study was to relate the levels of glucose, insulin, C-peptide, leptin and adiponectin in the maternal and umbilical vein serum to the birth weight in T1DM and healthy pregnancies. Methods. The study included 120 pregnant women divided into 4 groups: 30 suffering from type 1 diabetic pregnancy (T1DM) who gave birth to eutrophic and 30 who gave birth to macrosomic infants ; 30 from Control group (CTRL) who gave birth to eutrophic and 30 who gave birth to macrosomic infants. Serum insulin, C-peptide, leptin and adiponectin levels were quantified by ELISA. Results. Fetal macrosomia is associated with higher level of leptin in the fetal serum in both groups (T1DM: p=0.049 ; CTRL: p=0.031). Fetal levels of glucose and insulin have an influence on birth weight in the Control group (glucose: p=0.002 ; insulin: p=0.015). Adiponectin levels are higher in the maternal (p=0.001) and fetal serum (p<0.001) in eutrophic newborns of healthy pregnant women compared to the macrosomic newborns. Conclusion. The fetal growth is a complex process. Our results confirmed the relation between leptin and insulin levels and birth weight. They also suggest that adiponectin may be involved in the fetal growth.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080401-0385 - Dijabetes i metabolički sindrom nakon prethodnog gestacijskog dijabetesa (Marina Ivanišević, )

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Berberović, Edina; Ivanišević, Marina; Horvatiček, Marina; Kralik-Oguić, Saša; Đelmiš, Josip.
Utjecaj glukoze i adipokina na porođajnu težinu kod trudnica sa šećernom bolesti tipa 1 // Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 23 (2014), 4; 116-120 (međunarodna recenzija, članak, znanstveni)
Berberović, E., Ivanišević, M., Horvatiček, M., Kralik-Oguić, S. & Đelmiš, J. (2014) Utjecaj glukoze i adipokina na porođajnu težinu kod trudnica sa šećernom bolesti tipa 1. Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 23 (4), 116-120.
@article{article, year = {2014}, pages = {116-120}, keywords = {Adiponectin, Birthweight, Leptin, Pregnancy, Type 1 diabetes}, journal = {Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics}, volume = {23}, number = {4}, issn = {1330-0091}, title = {The relation of glucose and adipokines to birthweight in type 1 diabetic pregnancy}, keyword = {Adiponectin, Birthweight, Leptin, Pregnancy, Type 1 diabetes} }

Časopis indeksira:


  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • SCOPUS