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Pregled bibliografske jedinice broj: 788638

Genome-wide patterns of selection in 230 ancient Eurasians

Mathieson, Iain; Lazaridis, Iosif; Rohland, Nadin; Mallick, Swapan; Patterson, Nick; Alpaslan Roodenberg, Songül; Harney, Eadaoin; Stewardson, Kristin; Fernandes, Daniel; Novak, Mario et al.
Genome-wide patterns of selection in 230 ancient Eurasians // Nature, 528 (2015), 499-503 doi:10.1038/nature16152 (međunarodna recenzija, članak, znanstveni)

Genome-wide patterns of selection in 230 ancient Eurasians

Mathieson, Iain ; Lazaridis, Iosif ; Rohland, Nadin ; Mallick, Swapan ; Patterson, Nick ; Alpaslan Roodenberg, Songül ; Harney, Eadaoin ; Stewardson, Kristin ; Fernandes, Daniel ; Novak, Mario ; Sirak, Kendra ; Gamba, Cristina ; Jones, Eppie R. ; Llamas, Bastien ; Dryomov, Stanislav ; Pickrell, Joseph ; Arsuaga, Juan Luís ; Bermúdez de Castro, José María ; Carbonell, Eudald ; Gerritsen, Fokke ; Khokhlov, Aleksandr ; Kuznetsov, Pavel ; Lozano, Marina ; Meller, Harald ; Mochalov, Oleg ; Moiseyev, Vyacheslav ; Rojo Guerra, Manuel A. ; Roodenberg, Jacob ; Vergès, Josep Maria ; Krause, Johannes ; Cooper, Alan ; Alt, Kurt W. ; Brown, Dorcas ; Anthony, David ; Lalueza-Fox, Carles ; Haak, Wolfgang ; Pinhasi, Ron ; Reich, David

Nature (0028-0836) 528 (2015); 499-503

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ancient DNA; prehistory; Eurasia; natural selection

Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.

Izvorni jezik

Znanstvena područja


Institut za antropologiju

Autor s matičnim brojem:
Mario Novak, (266983)

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI