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Pregled bibliografske jedinice broj: 786142

Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent


Kukoc-Modun, Lea; Tsikas, Dimitrios; Biocic, Maja; Radić, Njegomir
Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent // Analytical letters, 49 (2016), 5; 607-617 doi:0.1080/00032719.2014.996811 (međunarodna recenzija, članak, znanstveni)


Naslov
Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)- neocuproine Reagent

Autori
Kukoc-Modun, Lea ; Tsikas, Dimitrios ; Biocic, Maja ; Radić, Njegomir

Izvornik
Analytical letters (0003-2719) 49 (2016), 5; 607-617

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cu(II)-neocuproine reagent ; flow-injection analysis ; N-acetyl-L-cysteine ; spectrophotometric determination

Sažetak
A novel flow-injection analysis spectrophotometric procedure for the determination of N-acetyl-L-cysteine in pharmaceutical formulations is reported. The method is based on the reduction of Cu(II)- neocuproine to Cu(I)-neocuproine by the sulfhydryl group of N-acetyl-L-cysteine in aqueous solution at pH = 3. The absorbance of the yellow Cu(I)-neocuproine complex was measured at 458 nanometers. The primary chemical and instrumental variables were examined thoroughly. The method was validated in terms of linear dynamic range, limit of detection, limit of quantitation, selectivity, precision, and accuracy. Measurements confirmed its suitability for the reliable determination of N-acetyl-L-cysteine in pharmaceutical preparations at a sampling rate of 180 analyses per hour.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
011-0000000-3217 - Određivanje tiola primjenom potenciometrijskih senzora i spektroskopije (Njegomir Radić, )

Ustanove
Kemijsko-tehnološki fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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