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Complexation properties of aromatic diureas


Barišić, Dajana; Cindro, Nikola; Bregović Nikola; Frkanec, Leo; Užarević, Krunoslav; Tomišić, Vladislav
Complexation properties of aromatic diureas // Pharma NMR Conference Application of NMR Spectroscopy in Pharmaceutical Industry : abstracts / Bregović, Nikola (ur.).
Zagreb: IAPC, 2015. str. 17-17 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Complexation properties of aromatic diureas

Autori
Barišić, Dajana ; Cindro, Nikola ; Bregović Nikola ; Frkanec, Leo ; Užarević, Krunoslav ; Tomišić, Vladislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharma NMR Conference Application of NMR Spectroscopy in Pharmaceutical Industry : abstracts / Bregović, Nikola - Zagreb : IAPC, 2015, 17-17

Skup
Pharma NMR Conference Application of NMR Spectroscopy in Pharmaceutical Industry

Mjesto i datum
Rovinj, Hrvatska, 23.-25.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Urea ; complexation ; NMR ; UV

Sažetak
The design of molecules which are capable to recognize and bind target anions is a vibrant area of modern research. Systematic research of anion coordination during the last few decades introduced a vast number of receptors for negatively charged species, mainly based on the binding functionalities equipped with hydrogen bond donors. The urea group is often used in such receptors due to its stability in acidic environment and the ability to form strong hydrogen bonds with certain anions. However, it has become evident that compounds containing a single urea moiety lack selectivity and rather rarely allow specific anion recognition. On the other hand, by linking two urea moieties via benzene, rigidity of the binding site is induced and significant increase in selectivity towards anions and stability of corresponding complexes can be achieved. In this work we have synthesized new phenyl diurea receptors (1a-d) and investigated both steric and resonance effects of the substituents on their complexation properties. In order to quantify binding affinities of anion receptors 1a-d towards several anions and to get a detailed insight into the processes occurring in the solutions, NMR and UV-VIS titrations were used.

Izvorni jezik
Engleski

Znanstvena područja
Kemija