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Pregled bibliografske jedinice broj: 783714

Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria


Kovač Šižgorić, Matilda; Sabol, Zlatko; Sabol, Filip; Delin, Sanja; Krakar, Goran; Đuranović, Vlasta
Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria // European Journal of Paediatric Neurology, Volume 19, Supplement 1, May 2015. Programme and Abstracts of EPNS 2015, 11th Congress of the European Paediatric Neurology Society, May 27-30, 2015 - Vienna, Austria
Beč, Austrija, 2015. str. 90-91 (poster, međunarodna recenzija, sažetak, stručni)


CROSBI ID: 783714 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria

Autori
Kovač Šižgorić, Matilda ; Sabol, Zlatko ; Sabol, Filip ; Delin, Sanja ; Krakar, Goran ; Đuranović, Vlasta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Journal of Paediatric Neurology, Volume 19, Supplement 1, May 2015. Programme and Abstracts of EPNS 2015, 11th Congress of the European Paediatric Neurology Society, May 27-30, 2015 - Vienna, Austria / - , 2015, 90-91

Skup
11th European Paediatric Neurology Society Congress 2015, May 27-30, 2015 - Vienna, Austria

Mjesto i datum
Beč, Austrija, 27-30.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
T2-hyperintensities ; brain MRI ; neurofibromatosis 1 ; children ; diagnostic criteria

Sažetak
Objective Neurofibromatosis 1 (NF1) is autosomal dominant inherited disorder often difficult to diagnose in children besause of its age-dependent presentation. The early diagnosis using National Intitutes of Health (so called NIH-criteria) cannot be made on the basis of routine clinical and ophthalmological examinations in all children, especially in patients of early age and in sporadic cases. T2-hyperintensities on brain MRI has been suggested as a new diagnostic sign. The aim of this study was to compare the degree of diagnostic accuracy T2-hyperintensity versus diagnostic accuracy NIH diagnostic changes. Methods We performed a cross-sectional study of 162 children with NF1 from Croatian Neurofibromatosis Association Database and 163 control children between the ages of 2 and 18 years who underwent brain MRI during twenty year period. In this study we used the basic reference standard – NIH diagnostic criteria for NF1 to determine or exclude a definitive clinical diagnosis of NF1. Results Multiple T2- hyperintensities on brain MRI had excellent diagnostic accuracy with the area under the ROC curve of 0.849, estimated on the whole group subjects aged 2–18 years. The diagnostic accuracy of T2-hyperintensities for NF1 were highest in the youngest age (2–8 years). At that age diagnostic accuracy of multiple T2-hyperintensities was significantly higher than diagnostic accuracy of majority of NIH-diagnostic signs – neurofibromas, freckling in the axillary or inguinal region, Lisch nodules, optic gliomas, a distinctive osseous lesions (p<0.001), respectively, except for multiple café au lait spots which had significantly the highest diagnostic accuracy than all above mentioned changes (P <0.001). Conclusion Significant higher levels of multiple T2- hyperintensities in comparison to most of the NIH diagnostic criteria, especially in the early children's age, confirm of justifiableness of their inclusion in the major NF1 diagnostic criteria and the need to revise the current NIH diagnostic criteria NF1 in children.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
072-1081870-0025 - Neurorazvojni ishod djece s intrauterinim zastojem rasta i/ili hipoksijom (Mejaški-Bošnjak, Vlatka, MZOS ) ( POIROT)

Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Opća bolnica Zadar

Profili:

Avatar Url Zlatko Sabol (autor)

Avatar Url Sanja Delin (autor)

Avatar Url Vlasta Đuranović (autor)

Avatar Url Goran Krakar (autor)

Citiraj ovu publikaciju:

Kovač Šižgorić, Matilda; Sabol, Zlatko; Sabol, Filip; Delin, Sanja; Krakar, Goran; Đuranović, Vlasta
Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria // European Journal of Paediatric Neurology, Volume 19, Supplement 1, May 2015. Programme and Abstracts of EPNS 2015, 11th Congress of the European Paediatric Neurology Society, May 27-30, 2015 - Vienna, Austria
Beč, Austrija, 2015. str. 90-91 (poster, međunarodna recenzija, sažetak, stručni)
Kovač Šižgorić, M., Sabol, Z., Sabol, F., Delin, S., Krakar, G. & Đuranović, V. (2015) Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria. U: European Journal of Paediatric Neurology, Volume 19, Supplement 1, May 2015. Programme and Abstracts of EPNS 2015, 11th Congress of the European Paediatric Neurology Society, May 27-30, 2015 - Vienna, Austria.
@article{article, year = {2015}, pages = {90-91}, keywords = {T2-hyperintensities, brain MRI, neurofibromatosis 1, children, diagnostic criteria}, title = {Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria}, keyword = {T2-hyperintensities, brain MRI, neurofibromatosis 1, children, diagnostic criteria}, publisherplace = {Be\v{c}, Austrija} }
@article{article, year = {2015}, pages = {90-91}, keywords = {T2-hyperintensities, brain MRI, neurofibromatosis 1, children, diagnostic criteria}, title = {Value of multiple T2-hyperintensities on brain MRI as a diagnostic criterion for neurofibromatosis 1 in children: Comparison of the diagnostic accuracy of T2-hyperintensities versus the National Institutes of Health criteria}, keyword = {T2-hyperintensities, brain MRI, neurofibromatosis 1, children, diagnostic criteria}, publisherplace = {Be\v{c}, Austrija} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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