Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 783619

ABC transporters in antibiotic clusters


Bošnjak, Ivana; Pustijanac, Emina; Kovačić, Ines; Bielen, Ana
ABC transporters in antibiotic clusters // Proceedings of the fifth Central European Symposium on Antimicrobials and Antimicrobial Resistance / Maravić Vlahoviček, Gordana ; Šegvić Klarić, Maja ; Abram, Maja ; Vidučić, Darija (ur.).
Zagreb: Croatian Microbiological Society, 2015. str. 65-65 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 783619 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
ABC transporters in antibiotic clusters

Autori
Bošnjak, Ivana ; Pustijanac, Emina ; Kovačić, Ines ; Bielen, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the fifth Central European Symposium on Antimicrobials and Antimicrobial Resistance / Maravić Vlahoviček, Gordana ; Šegvić Klarić, Maja ; Abram, Maja ; Vidučić, Darija - Zagreb : Croatian Microbiological Society, 2015, 65-65

ISBN
978-953-7778-12-5

Skup
The fifth Central European Symposium on Antimicrobials and Antimicrobial Resistance - CESAR 2015

Mjesto i datum
Šibenik, Hrvatska, 23-26.9.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ABC transporters; Antibiotic clusters

Sažetak
ATP-binding cassette (ABC) proteins utilize ATP to act as uptake or efflux transporters. ABC protein superfamily is one of the largest groups of proteins, found in all organisms. Among numerous other functions, they can be involved in the secretion of antibiotics through the cell membrane. Therefore, they contribute significantly to self-resistance of the producing organisms, but also of other species, including important pathogens. Identification of antibiotic efflux- transporters can help in the development of more efficient antibiotic production systems. Also, design of specific inhibitors of antibiotic efflux is important for the improved control of multidrug-resistant strains of bacteria. The aim of our work was to collect and classify ABC transporters that are present in antibiotic- producing gene clusters. We have retrieved 320 previously described antibiotic gene clusters from diverse prokaryotic and eukaryotic microorganisms and found that 31.9 % of them contained at least one ABC transporter sequence. Out of 74 Pfam families belonging to the ABC superfamily according to the Transporter Classification Database (TCDB), we have found 29 in antibiotic clusters. Interestingly, only 1 ABC transporter sequence was found in eukaryotic (fungal) antibiotic-producing clusters. We will present preliminary results of clustering and phylogenetic analysis of the retrieved 246 ABC transporters sequences and compare the identified groups regarding their presumed physiological role and transport mechanism. Overall, our results will provide a systematization of knowledge on ABC transporters that are present in antibiotic- producing gene clusters, and easy implementation to newly identified transporters.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija



POVEZANOST RADA


Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Sveučilište Jurja Dobrile u Puli

Profili:

Avatar Url Emina Pustijanac (autor)

Avatar Url Ivana Babić (autor)

Avatar Url Ana Bielen (autor)

Avatar Url Ines Kovačić (autor)


Citiraj ovu publikaciju:

Bošnjak, Ivana; Pustijanac, Emina; Kovačić, Ines; Bielen, Ana
ABC transporters in antibiotic clusters // Proceedings of the fifth Central European Symposium on Antimicrobials and Antimicrobial Resistance / Maravić Vlahoviček, Gordana ; Šegvić Klarić, Maja ; Abram, Maja ; Vidučić, Darija (ur.).
Zagreb: Croatian Microbiological Society, 2015. str. 65-65 (poster, međunarodna recenzija, sažetak, znanstveni)
Bošnjak, I., Pustijanac, E., Kovačić, I. & Bielen, A. (2015) ABC transporters in antibiotic clusters. U: Maravić Vlahoviček, G., Šegvić Klarić, M., Abram, M. & Vidučić, D. (ur.)Proceedings of the fifth Central European Symposium on Antimicrobials and Antimicrobial Resistance.
@article{article, author = {Bo\v{s}njak, Ivana and Pustijanac, Emina and Kova\v{c}i\'{c}, Ines and Bielen, Ana}, year = {2015}, pages = {65-65}, keywords = {ABC transporters, Antibiotic clusters}, isbn = {978-953-7778-12-5}, title = {ABC transporters in antibiotic clusters}, keyword = {ABC transporters, Antibiotic clusters}, publisher = {Croatian Microbiological Society}, publisherplace = {\v{S}ibenik, Hrvatska} }
@article{article, author = {Bo\v{s}njak, Ivana and Pustijanac, Emina and Kova\v{c}i\'{c}, Ines and Bielen, Ana}, year = {2015}, pages = {65-65}, keywords = {ABC transporters, Antibiotic clusters}, isbn = {978-953-7778-12-5}, title = {ABC transporters in antibiotic clusters}, keyword = {ABC transporters, Antibiotic clusters}, publisher = {Croatian Microbiological Society}, publisherplace = {\v{S}ibenik, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font