Biocompatibility of silver nanoparticles as function of surface functionalization: a neural stem cell model (CROSBI ID 628832)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Pavičić, Ivan ; Milić, Mirta ; Pongrac, Igor ; Ćurlin, Marija ; Jurašin, Darija ; Vinković Vrček, Ivana ; Gajović, Srećko
engleski
Biocompatibility of silver nanoparticles as function of surface functionalization: a neural stem cell model
Silver nanoparticles (AgNPs) are the most commonly used nanomaterials with focus on their biocidal activity commonly used for medical purposes. This study aimed to understand in vitro nanotoxicity by evaluating the effect of 5 different AgNPs (stabilized with different surface coating: sodium bis(2-ethylhexyl)-sulfosuccinate (AOTAgNP), cetyl trimethylammonium bromide (CTAAgNP), poly(vinylpyrrolidone) (PVPAgNP), poly-L-lysine (PLLAgNP), and bovine serum albumin (BSAAgNP)) on neural stem cells (NSC). For toxicity evaluations, cell viability and DNA damage in NSC were assessed using CCK-8 and alkaline comet assays, respectively. Significant decrease in cell viability after 24 h exposure for AOTAgNP, CTAAgNPs and PVPAgNPs was observed at 3 mg/L AgNP concentration, while PLLAgNPs and BSAAgNPs induced significant toxicity at concentration of 10 mg/L. Significant DNA damage was observed at 0.1 mg/L of BSAAgNPs, 0.5 mg/L of CTAAgNPs and PLLAgNPs, and 1 mg/L of PVPAgNPs and AOTAgNPs. Our results imply that much lower concentration of AgNPs is able to induce cyto- and genotoxicity in NSC compared to published results on other types of mammalian cells. (Supported by EU FP7 grant GlowBrain: REGPOT-2012-CT2012-316120.)
silver nanoparticles ; biocompatibility ; neural stem cells
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Podaci o prilogu
29-29.
2015.
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objavljeno
Podaci o matičnoj publikaciji
Journal of trace elements in medicine and biology
Jurasović, Jasna ; Aschner, Michael
Amsterdam: Elsevier
0946-672X
Podaci o skupu
ISTERH Conference Recent Advances in Trace Element Research in Health and Disease (11 ; 2015)
poster
18.10.2015-22.10.2015
Srebreno, Hrvatska
Povezanost rada
Kemija, Temeljne medicinske znanosti, Biologija