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Biocompatibility of silver nanoparticles as function of surface functionalization: a neural stem cell model (CROSBI ID 628832)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Pavičić, Ivan ; Milić, Mirta ; Pongrac, Igor ; Ćurlin, Marija ; Jurašin, Darija ; Vinković Vrček, Ivana ; Gajović, Srećko Biocompatibility of silver nanoparticles as function of surface functionalization: a neural stem cell model // Journal of trace elements in medicine and biology / Jurasović, Jasna ; Aschner, Michael (ur.). 2015. str. 29-29

Podaci o odgovornosti

Pavičić, Ivan ; Milić, Mirta ; Pongrac, Igor ; Ćurlin, Marija ; Jurašin, Darija ; Vinković Vrček, Ivana ; Gajović, Srećko

engleski

Biocompatibility of silver nanoparticles as function of surface functionalization: a neural stem cell model

Silver nanoparticles (AgNPs) are the most commonly used nanomaterials with focus on their biocidal activity commonly used for medical purposes. This study aimed to understand in vitro nanotoxicity by evaluating the effect of 5 different AgNPs (stabilized with different surface coating: sodium bis(2-ethylhexyl)-sulfosuccinate (AOTAgNP), cetyl trimethylammonium bromide (CTAAgNP), poly(vinylpyrrolidone) (PVPAgNP), poly-L-lysine (PLLAgNP), and bovine serum albumin (BSAAgNP)) on neural stem cells (NSC). For toxicity evaluations, cell viability and DNA damage in NSC were assessed using CCK-8 and alkaline comet assays, respectively. Significant decrease in cell viability after 24 h exposure for AOTAgNP, CTAAgNPs and PVPAgNPs was observed at 3 mg/L AgNP concentration, while PLLAgNPs and BSAAgNPs induced significant toxicity at concentration of 10 mg/L. Significant DNA damage was observed at 0.1 mg/L of BSAAgNPs, 0.5 mg/L of CTAAgNPs and PLLAgNPs, and 1 mg/L of PVPAgNPs and AOTAgNPs. Our results imply that much lower concentration of AgNPs is able to induce cyto- and genotoxicity in NSC compared to published results on other types of mammalian cells. (Supported by EU FP7 grant GlowBrain: REGPOT-2012-CT2012-316120.)

silver nanoparticles ; biocompatibility ; neural stem cells

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Podaci o prilogu

29-29.

2015.

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objavljeno

Podaci o matičnoj publikaciji

Journal of trace elements in medicine and biology

Jurasović, Jasna ; Aschner, Michael

Amsterdam: Elsevier

0946-672X

Podaci o skupu

ISTERH Conference Recent Advances in Trace Element Research in Health and Disease (11 ; 2015)

poster

18.10.2015-22.10.2015

Srebreno, Hrvatska

Povezanost rada

Kemija, Temeljne medicinske znanosti, Biologija

Indeksiranost