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Bisphenanthridinium – adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures


Tumir, Lidija-Marija; Šupljika, Filip; Piantanida, Ivo
Bisphenanthridinium – adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures // Supramolecular chemistry, 28 (2016), 3-4; 267-274 doi:10.1080/10610278.2015.1099655 (međunarodna recenzija, članak, znanstveni)


Naslov
Bisphenanthridinium – adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures

Autori
Tumir, Lidija-Marija ; Šupljika, Filip ; Piantanida, Ivo

Izvornik
Supramolecular chemistry (1061-0278) 28 (2016), 3-4; 267-274

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA recognition; phenanthridine-adenine conjugates; fluorimetric titration; CD titration

Sažetak
Two structurally similar bis-phenanthridinium- adenine conjugates (equipped with one or two adenines respectively), exhibiting strong ds- DNA/RNA groove binding, revealed ratiometric fluorescent recognition of alternating AT-DNA in respect to other ds-DNA/RNA and ss-RNA. Further, CD spectra pattern of adenine- bisphenanthridinium conjugate/polynucleotide complexes strongly depended on polynucleotide secondary structure. Attached adenine was essential for spectrophotometric recognition response, ds-DNA stabilization and orientation of compounds regarding chiral DNA helix.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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