engleski

Expression of PTCH1b Tumor Suppressor Gene Is Controlled by Different 5' Untranslated Region Cis-Regulatory Elements

PTCH1 tumor suppressor gene encodes for a transmembrane receptor with a negative regulatory role in Hedgehog-Gli signaling pathway, which is a highly conserved cellular mechanism for transducing signals from the cell surface into the nucleus. After identifying 5 to 8 CGG repeats close to translation initiation site, our aim was to examine how 5’UTR regulates the expression of PTCH1 gene main transcript 1b (PTCH1b). All our results point to the exceptionally complex and so far unexplored levels of PTCH1b expression regulation by 5’UTR. So far, we can assert that PTCH1b 5’UTR shares its characteristics with mRNAs coding for transcription factors, proto-oncogenes, growth factors and their receptors, or generally for proteins poorly translated under normal condition.

PTCH1; 5' Untranslated Region; Protein Translational Initiation; Trinucleotide Repeats; Open Reading Frames

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