Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 779872

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life


Perina, Dragutin; Mikoč, Andreja; Ahel, Josip; Ćetković, Helena; Žaja, Roko; Ahel, Ivan
Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life // DNA repair, 23 (2014), 4-16 doi:10.1016/j.dnarep.2014.05.003 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 779872 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

Autori
Perina, Dragutin ; Mikoč, Andreja ; Ahel, Josip ; Ćetković, Helena ; Žaja, Roko ; Ahel, Ivan

Izvornik
DNA repair (1568-7864) 23 (2014); 4-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Poly(ADP-ribose) ; PARP ; PARG ; Macrodomain ; DNA damage response

Sažetak
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in regulation of many cellular pathways. Poly(ADP-ribose) (PAR) consists of chains of repeating ADP-ribose nucleotide units and is synthesized by the family of enzymes called poly(ADP-ribose) polymerases (PARPs). This modification can be removed by the hydrolytic action of poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosylhydrolase 3 (ARH3). Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation. Poly(ADP-ribosyl)ation is widely utilized in eukaryotes and PARPs are present in representatives from all six major eukaryotic supergroups, with only a small number of eukaryotic species that do not possess PARP genes. The last common ancestor of all eukaryotes possessed at least five types of PARP proteins that include both mono and poly(ADP-ribosyl) transferases. Distribution of PARGs strictly follows the distribution of PARP proteins in eukaryotic species. At least one of the macrodomain proteins that hydrolyse terminal ADP-ribose is also always present. Therefore, we can presume that the last common ancestor of all eukaryotes possessed a fully functional and reversible PAR metabolism and that PAR signalling provided the conditions essential for survival of the ancestral eukaryote in its ancient environment. PARP proteins are far less prevalent in bacteria and were probably gained through horizontal gene transfer. Only eleven bacterial species possess all proteins essential for a functional PAR metabolism, although it is not known whether PAR metabolism is truly functional in bacteria. Several dsDNA viruses also possess PARP homologues, while no PARP proteins have been identified in any archaeal genome. Our analysis of the distribution of enzymes involved in PAR metabolism provides insight into the evolution of these important signalling systems, as well as providing the basis for selection of the appropriate genetic model organisms to study the physiology of the specific human PARP proteins.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Roko Žaja (autor)

Avatar Url Helena Ćetković (autor)

Avatar Url Ivan Ahel (autor)

Avatar Url Andreja Mikoč (autor)

Avatar Url Dragutin Perina (autor)

Citiraj ovu publikaciju

Perina, Dragutin; Mikoč, Andreja; Ahel, Josip; Ćetković, Helena; Žaja, Roko; Ahel, Ivan
Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life // DNA repair, 23 (2014), 4-16 doi:10.1016/j.dnarep.2014.05.003 (međunarodna recenzija, članak, znanstveni)
Perina, D., Mikoč, A., Ahel, J., Ćetković, H., Žaja, R. & Ahel, I. (2014) Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life. DNA repair, 23, 4-16 doi:10.1016/j.dnarep.2014.05.003.
@article{article, year = {2014}, pages = {4-16}, DOI = {10.1016/j.dnarep.2014.05.003}, keywords = {Poly(ADP-ribose), PARP, PARG, Macrodomain, DNA damage response}, journal = {DNA repair}, doi = {10.1016/j.dnarep.2014.05.003}, volume = {23}, issn = {1568-7864}, title = {Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life}, keyword = {Poly(ADP-ribose), PARP, PARG, Macrodomain, DNA damage response} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font