Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 779853

Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula


Perina, Dragutin; Korolija, Marina; Popović Hadžija, Marijana; Grbeša, Ivana; Belužić, Robert; Imešek, Mirna; Morrow, Christine; Posavec Marjanović, Melanija; Bakran-Petricioli, Tatjana; Mikoč, Andreja; Ćetković, Helena
Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula // Marine drugs, 13 (2015), 7; 4179-4196 doi:10.3390/md13074179 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 779853 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula

Autori
Perina, Dragutin ; Korolija, Marina ; Popović Hadžija, Marijana ; Grbeša, Ivana ; Belužić, Robert ; Imešek, Mirna ; Morrow, Christine ; Posavec Marjanović, Melanija ; Bakran-Petricioli, Tatjana ; Mikoč, Andreja ; Ćetković, Helena

Izvornik
Marine drugs (1660-3397) 13 (2015), 7; 4179-4196

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ribosomal protein genes; snoRNA; FAU; RPS30; SNORA62; evolution; Porifera

Sažetak
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large majority of genes implicated in human cancers have their homologues in the sponge genome. Our study suggests that FAU gene from the sponge Suberites domuncula reflects characteristics of the FAU gene from the metazoan ancestor, which have changed only slightly during the course of animal evolution. We found pro-apoptotic activity of sponge FAU protein. The same as its human homologue, sponge FAU increases apoptosis in human HEK293T cells. This indicates that the biological functions of FAU, usually associated with “higher” metazoans, particularly in cancer etiology, possess a biochemical background established early in metazoan evolution. The ancestor of all animals possibly possessed FAU protein with the structure and function similar to evolutionarily more recent versions of the protein, even before the appearance of true tissues and the origin of tumors and metastasis. It provides an opportunity to use pre-bilaterian animals as a simpler model for studying complex interactions in human cancerogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982913-2874 - Geni i genomi: struktura, funkcija i evolucija (Helena Ćetković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Perina, Dragutin; Korolija, Marina; Popović Hadžija, Marijana; Grbeša, Ivana; Belužić, Robert; Imešek, Mirna; Morrow, Christine; Posavec Marjanović, Melanija; Bakran-Petricioli, Tatjana; Mikoč, Andreja; Ćetković, Helena
Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula // Marine drugs, 13 (2015), 7; 4179-4196 doi:10.3390/md13074179 (međunarodna recenzija, članak, znanstveni)
Perina, D., Korolija, M., Popović Hadžija, M., Grbeša, I., Belužić, R., Imešek, M., Morrow, C., Posavec Marjanović, M., Bakran-Petricioli, T., Mikoč, A. & Ćetković, H. (2015) Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. Marine drugs, 13 (7), 4179-4196 doi:10.3390/md13074179.
@article{article, year = {2015}, pages = {4179-4196}, DOI = {10.3390/md13074179}, keywords = {ribosomal protein genes, snoRNA, FAU, RPS30, SNORA62, evolution, Porifera}, journal = {Marine drugs}, doi = {10.3390/md13074179}, volume = {13}, number = {7}, issn = {1660-3397}, title = {Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula}, keyword = {ribosomal protein genes, snoRNA, FAU, RPS30, SNORA62, evolution, Porifera} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati