Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference (CROSBI ID 221320)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kurzbach, Dennis ; Vanas, Agathe ; Flamm, Andrea G. ; Tarnoczi, Nicole ; Kontaxis, Georg ; Maltar-Strmečki, Nadica ; Widder, Katharina ; Hinderberger, Dariush ; Konrat, Robert
engleski
Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference
Functionally relevant conformational states of intrinsically disordered proteins (IDPs) are typically concealed in a vast space of fast interconverting structures. Here we present a novel methodology, NMR-based paramagnetic relaxation interference (PRI), that allows for direct observation of concerted motions and cooperatively folded sub-states in IDPs. The proposed NMR technique is based on the exploitation of cross correlated electron- nuclear dipolar relaxation interferences in doubly spin- labeled proteins and probes the transient spatial encounter of electron-nucleus spin pairs.
disordered proteins ; relaxation ; NMR-based paramagnetic relaxation interference
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Podaci o izdanju
18 (8)
2016.
5753-5758
objavljeno
1463-9076
10.1039/C5CP04858C