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Pregled bibliografske jedinice broj: 778381

DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH


Habinovec, Iva; Car, Željka; Ribić, Rosana; Biljan, Ivana; Pičuljan, Katarina; Galić, Nives; Novak, Predrag; Tomić, Srđanka; Meštrović, Ernest
DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH // Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry / Novak, Predrag ; Tomišić, Vladislav ; Bregović, Nikola (ur.).
Zagreb: IAPC, 2015. str. 25-25 (poster, domaća recenzija, sažetak, ostalo)


Naslov
DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH

Autori
Habinovec, Iva ; Car, Željka ; Ribić, Rosana ; Biljan, Ivana ; Pičuljan, Katarina ; Galić, Nives ; Novak, Predrag ; Tomić, Srđanka ; Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry / Novak, Predrag ; Tomišić, Vladislav ; Bregović, Nikola - Zagreb : IAPC, 2015, 25-25

Skup
Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry

Mjesto i datum
Crveni otok, Rovinj, Hrvatska, 23.-25.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
7-Ethyltryptophol; Purity; Structures of impurities; HPLC method; LC-SPE-NMR analysis

Sažetak
7-Ethyltryptophol, 2(7-ethyl-1H-indol-3- yl)ethanol, is a key starting material in the synthesis of Etodolac, a non-steroidal anti- inflammatory drug (Scheme 1). Depending on the synthetic pathway for 7- ethyltryptophol, commercially available material comprises many different impurities which can cause formation of coproducts in the synthesis of Etodolac thus complicating the purification of the final product.[1] Therefore, to develop an optimal purification procedure of Etodolac, it is important to know the structures of impurities in 7- ethyltryptophol. LC-SPE-NMR methodology is a powerful tool for fast identification and structural elucidation of low concentration level impurities and degradation products in pharmaceuticals.[2] In this study we report on the HPLC method for efficient separation of impurities in 7- ethyltryptophol as the first step in hyphenated LC-SPE-NMR analysis. References 1. M. C. Sekharayya, G. V. Narayana, S. Nigam, G. Madhusudhan, Indian J. Chem. 51B (2012) 1763-1766. 2. S. Singh, T. Handa, M. Narayanam, A. Sahu, M. Junwal, R. P. Shah, J. Pharm. Biomed. Anal. 69 (2012) 148-173. Acknowledgements: This work was funded by European Regional Development Fund and Croatian state budget (project Met4Pharm).

Izvorni jezik
Engleski

Znanstvena područja
Kemija