Naslov
Synthesis of hybrid hydrazino peptides: protected vs unprotected chiral α-hydrazino acids

Autori
Suć, Josipa ; Jerić, Ivanka

Izvornik
SpringerPlus (2193-1801) 4 (2015); 507-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acylation ; amino acids ; peptidomimetics ; synthetic methods

Sažetak
Peptidomimetics based on hydrazino derivatives of α-amino acids represent an important class of peptidic fol- damers with promising biological activities, like protease inhibition and antimicrobial activity. However, the lack of straightforward method for the synthesis of optically pure hydrazino acids and efficient incorporation of hydrazino building blocks into peptide sequence hamper wider exploitation of hydrazino peptidomimetics. Here we described the utility of Nα-benzyl protected and unprotected hydrazino derivatives of natural α- amino acids in synthesis of peptidomimetics. While incorporation of Nα-benzyl-hydrazino acids into peptide chain and deprotection of benzyl moiety proceeded with difficulties, unprotected hydrazino acids allowed fast and simple construction of hybrid peptidomimetics.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA