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Pregled bibliografske jedinice broj: 776114

Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome


Markeljević, Jasenka; Šarac, Helena; Božina, Nada; Henigsberg, Neven; Šimić, Mirjana; Čičin- Šain, Lipa
Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome // Journal of neuroimmunology, 282 (2015), 104-109 doi:10.1016/j.jneuroim.2015.04.002 (međunarodna recenzija, članak, znanstveni)


Naslov
Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome

Autori
Markeljević, Jasenka ; Šarac, Helena ; Božina, Nada ; Henigsberg, Neven ; Šimić, Mirjana ; Čičin- Šain, Lipa

Izvornik
Journal of neuroimmunology (0165-5728) 282 (2015); 104-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-HTTLPR/rs25531; 5-HTTVNTRin2; Platelet serotonin; Serotonin transporter polymorphism; Sjogren syndrome

Sažetak
Significantly lower platelet serotonin level (PSL) in patients with primary Sjogren's syndrome (pSS) than in healthy controls has been reported in our prior studies. In the present report, we demonstrated effect of functional polymorphisms in the serotonin transporter gene (5-HTT) on PSL. We describe a group of 61 pSS patients and 100 healthy individuals subjects, who received PSL measurement in our prior study. All subjects were genotyped for the promoter 5-HTTLPR (L/S), rs25531 (A/G) and intronic 5-HTTVNTRin2 (l/s) polymorphisms. Overall, the presence of 5- HTTVNTRin2 ss genotype was associated with significantly lower PSL in pSS patients, not in healthy controls. Reduced PSL in pSS patients is in line with hypothesis of association between chronic immunoinflammation and 5-HT system dysregulation, identifying additional mechanisms such as altered 5-HT transport as potential genetic factor contributing to PSL depletion.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Lipa Čičin-Šain, )
108-1081874-2416 - Sjögrenov sindrom - neurohumoralna regulacija autoimunosti i aterogeneza (Jasenka Markeljević, )

Ustanove
Imunološki zavod d.d.,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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