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Synthesis of new oxadiazole based antioxidants

Oxadiazoles are a class of heterocyclic compounds with a wide range of biological activities. Their combination with coumarin core is interesting synthetic approach and could yield some new biologically active compounds including antioxidants. A series of new oxadiazoles was synthesized from coumarin Schiff bases in reaction with acetic anhydride. Their structure was confirmed with various spectral techniques and their antioxidant activity was determined as DPPH scavenging activity. A combination of coumarin core with oxadiazole ring was found to be an excellent approach for obtaining antioxidants, since some compounds had an excellent antioxidant activity.

Oxadiazole; Coumarin; Antioxidants

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