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Pregled bibliografske jedinice broj: 773961

Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial


Štimac, Davor; Poropat, Goran; Hauser, Goran; Licul, Vanja; Franjić, Neven; Valković- Zujić, Petra; Milić, Sandra
Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial // Pancreatology, 16 (2016), 4; 523-528 doi:10.1016/j.pan.2016.04.003 (međunarodna recenzija, članak, znanstveni)


Naslov
Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial

Autori
Štimac, Davor ; Poropat, Goran ; Hauser, Goran ; Licul, Vanja ; Franjić, Neven ; Valković- Zujić, Petra ; Milić, Sandra

Izvornik
Pancreatology (1424-3903) 16 (2016), 4; 523-528

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute necrotizing pancreatitis; complications; enteral nutrition; fasting; mortality

Sažetak
BACKGROUND/OBJECTIVES: There is substantial evidence of superiority of enteral nutrition (EN) to parenteral nutrition in acute pancreatitis (AP) treatment, but few studies evaluated its effectiveness compared to no intervention. The objective of our trial was to compare the effects of EN to a nil-by-mouth (NBM) regimen in patients with AP. METHODS: Patients with AP were randomized to receive either EN via a nasojejunal tube initiated within 24 h of admission or no nutritional support. Systemic inflammatory response syndrome (SIRS) was assessed as the primary outcome. Secondary outcomes included mortality, organ failure, local complications, infected pancreatic necrosis, surgical interventions, length of hospital stay, adverse events and inflammatory response intensity. Outcomes were compared using Student's t-test and Mann- Whitney U test as appropriate. RESULTS: 214 patients were randomized in total, 107 to each group. SIRS occurrence was similar between groups, with 48 (45%) versus 51 (48%), respectively (RR 0.94 ; 95% CI 0.71-1.26). No significant reduction of persistent organ failure (RR 0.81 ; 95% CI 0.52-1.27) and mortality (RR 0.59 ; 95% CI 0.28-1.23) was present in the EN group. There were no significant differences in other outcomes between the groups. When analyzing the occurrence of SIRS and mortality in subgroup of patients with severe disease no significant differences were noted. CONCLUSION: Our results showed no significant reduction of persistent organ failure and mortality in patients with AP receiving early EN compared to patients treated with no nutritional support (NCT01965873).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-0211 - Učinci enteralne prehrane u teškom akutnom pankreatitisu (Davor Štimac, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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