engleski

Determination of bisphenol A in thermochromic printing inks by HPLC

Bisphenol A (BPA ; Figure 1) is an industrial chemical with major applications in the production of polycarbonate plastics and epoxy resins. Polycarbonate is used in food storage containers, while epoxy resins are used in the internal coating for food and beverage cans. Residues of unreacted BPA can migrate into foods, and humans of different age are inevitably exposed to it. BPA acts as endocrine-disrupting compound that perturb the endocrine system either by acting as agonist or antagonist to sex hormone receptors, thus mimicking or preventing the action of endogenous estrogens and androgens. In this work BPA was determined in 3 out of 5 samples of thermochromic printing inks by gradient HPLC method. The samples were sonicated in ultrasound bath, diluted with mobile phase (acetonitrile/water 1/1) and filtered prior to analyses. The mass ratio of BPA in dyes ranged from 2.15 to 4.42 %. Unusually high results were confirmed by comparison of peak areas of BPA in standard and in dyes at two wavelengths (228 nm and 278 nm), and the ratio of peak areas was the same. Limits of detection (LOD) of BPA ranged from 9.5 to 33.5 μg/kg, whereas limits of quantification (LOQ) ranged from 28.6 to 56.0 μg/kg.

bisphenol A ; HPLC ; LOQ ; LOD

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