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Zn2+ Interferences with N-Sulfonylpyrimidine Derivatives (CROSBI ID 626477)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Kobetić, Renata ; Ključarić, Valentina ; Matić, Josipa ; Saftić, Dijana ; Ban, Željka ; Žinić, Biserka Zn2+ Interferences with N-Sulfonylpyrimidine Derivatives // XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Ukić, Šime ; Bolanča, Tomislav (ur.). Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2015. str. 186-186

Podaci o odgovornosti

Kobetić, Renata ; Ključarić, Valentina ; Matić, Josipa ; Saftić, Dijana ; Ban, Željka ; Žinić, Biserka

engleski

Zn2+ Interferences with N-Sulfonylpyrimidine Derivatives

The aim of this report is to present the ESI MS results of the non-covalent interaction of sulfonamide derivatives of cytosine nucleobase (very good antitumor agent - the inhibitory effect on enzymes that play an important role in the metabolism of tumor cells) with biologically important metal cations since the cells growing media consists of a significant amount of dissolved different salts. Although all components of the media are prone to interact with the agent, the metal ions (Na+, K+, Ca2+, Mg2+, Zn2+, Fe2+) were in focus in this study. Two ligands N-1-(p-toulenesulfonyl)cytosine, 1-TsC, and N-1-(methanesulfonyl)cytosine, 1-MsC, as well as their copper (II) complexes: mononuclear complex Cu(1-TsC-N3)2Cl2, containing 1-TsC, as ligand and Cu(1-MsC-N3)2Cl2 containing 1-MsC, as ligand were studied. The study elaborated the stability of ligands, and copper complexes in solutions (DMSO/MeOH or H2O or ACN and DMF/ MeOH or H2O or ACN) and possible non-covalent interaction. In cases in which comparisons can be made, the gas-phase results show unexpectedly strong analogies to those observed in the condensed phase. For example the interaction of Zn2+ with ligands, or copper complexes produced a variety of complex ions as a result of its affinity towards both O and N as ligands. We observed the formation of monometal Zn2+ complexes (e.g. signal observed at m/z 858 assigned as [(1-TsC)3(-H)Zn]+) and mixed ligand dimetal complexes that included water molecules in the structures of complexes (e.g. signal observed at m/z 894 assigned as [(1-TsC)3(-H)Zn(H2O)2]2 2+). The interferences of Zn2+ ions with copper complexes were observed. Therefore, the interferences of potential drug and metal ions could be predicted before pursuing the biological studies.

N-Sulfonylpyrimidines ; Zn2+ Complexes

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Podaci o prilogu

186-186.

2015.

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objavljeno

978-953-6894-54-3

Podaci o matičnoj publikaciji

XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka

Ukić, Šime ; Bolanča, Tomislav

Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)

Podaci o skupu

XXIV. hrvatski skup kemičara i kemijskih inženjera

poster

21.04.2015-24.04.2015

Zagreb, Hrvatska

Povezanost rada

Kemija