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Fluorophore-tagged Nucleobase Derivatives


Saftić, Dijana; Žinić, Biserka; Radić Stojković, Marijana; Tumir, Lidija-Marija; Piantanida, Ivo
Fluorophore-tagged Nucleobase Derivatives // XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Ukić, Šime ; Bolanča, Tomislav (ur.).
Zagreb: HDKI/CSCE, 2015. str. 148-148 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Fluorophore-tagged Nucleobase Derivatives

Autori
Saftić, Dijana ; Žinić, Biserka ; Radić Stojković, Marijana ; Tumir, Lidija-Marija ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Ukić, Šime ; Bolanča, Tomislav - Zagreb : HDKI/CSCE, 2015, 148-148

ISBN
978-953-6894-54-3

Skup
XXIV. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 21.-24.04.2015.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Nukleobaze; click kemija; fluorescentni konjugati
(Nucleobases; Click Chemistry; Fluorescence Conjugates)

Sažetak
Novel 1, 4-disubstituted-1, 2, 3-triazole pyrimidines were synthesized applying the copper(I)-catalysed azide–alkyne cycloaddition (CuAAC). Beside intrinsically fluorescent triazole ring (well-known pharmacophore), various substituents (originating from different azide precursors) additionally enable a wide range of applications of new derivatives. For instance, 1, 2, 3-triazole ring can noncovalently interact with DNA/RNA by hydrogen bonding and aromatic stacking interactions and spectrophotometrically report on small structural differences of DNA as well as RNA secondary structure. Novel triazole-nucleobase derivatives were prepared as amino acids with both, N- and C- enabled coupling, which allows easy and versatile incorporation into large variety of novel oligopeptides for various applications. Furthermore, triazole-nucleobase was combined with phenanthridine, later added with the aim to increase DNA/RNA affinity and contribute to the spectrophotometric recognition, thus yielding dual-fluorescence reporter conjugate.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb