MMP-2-1575 G/A polymorphism modifiesthe onset of optic neuritis as a first presenting symptom in MS? (CROSBI ID 220179)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Gasparović, Iva ; Starčević Čizmarević, Nada ; Lovrečić, Luca ; Perković, Olivio ; Lavtar, Polona ; Sepčić, Juraj ; Šega Jazbec, Saša ; Kapović, Miljenko ; Peterlin, Borut ; Ristić, Smiljana
engleski
MMP-2-1575 G/A polymorphism modifiesthe onset of optic neuritis as a first presenting symptom in MS?
Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and cerebrospinal fluid of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Optic neuritis (ON) is a common symptom of both disorders. Here we investigated the impacts of MMP-2-1575 G/A and MMP-9-1562 C/T gene polymorphisms on disease phenotype in 100 MS patients with ON as a first symptom and 376 MS patients with other initial symptomatology. The MMP-2-1575 G/A polymorphism led to a 5-year- earlier age of disease onset in MS patients with ON as a first symptom (p= 0.009)
multiple sclerosis ; optic neuritis ; MMP-2 ; MMP-9 ; susceptibility ; age of disease onset
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti