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Pregled bibliografske jedinice broj: 770439

A Multidisciplinary Approach to the Study of Adamantyl Aminoguanidines, a New Class of Potentially Bioactive Compounds


Šekutor, Marina
A Multidisciplinary Approach to the Study of Adamantyl Aminoguanidines, a New Class of Potentially Bioactive Compounds // 7th Young Investigators Workshop
Aveiro, Portugal, 2015. str. L25-L25 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
A Multidisciplinary Approach to the Study of Adamantyl Aminoguanidines, a New Class of Potentially Bioactive Compounds

Autori
Šekutor, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Young Investigators Workshop / - Aveiro, Portugal, 2015, L25-L25

Skup
7th Young Investigators Workshop

Mjesto i datum
Aveiro, Portugal, 9-11.07.2015

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Aminoguanidines ; Adamantane ; Bioactive compounds ; Pharmacophores

Sažetak
Adamantane is a common structural motif in a number of bioactive compounds due to its unique properties such as high lipophilicity and chemical inertness [1]. Adamantane-containing derivatives have been used in medicinal chemistry for more than 50 years and the discovery of new polycyclic drugs continues up to the present day [2]. The goal of this study was to combine the lipophilic adamantyl fragment with a highly polar guanidine moiety in order to see how that kind of a system would work and to search for new properties and possible applications of such molecules. The intention was also to add variety in the type and the nature of the bond connecting these two systems and therefore we used the aminoguanidine subunit. The resulting adamantyl aminoguanidines are compounds with a high potential of use as pharmacophores but their preparation and characterization has only recently been described [3]. Here a detailed study of this class of compounds is presented, with special emphasis on their physico-chemical properties as well as the evaluation of the possibilities of their biological application.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Kata Majerski, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Marina Šekutor, (312901)