engleski

Autologous conditioned serum as an adjunct to nonsurgical periodontal therapy of aggressive periodontitis

Aim: The aim of this research was to determine the effectiveness of autologous conditioned serum (ACS) as an adjunct to nonsurgical periodontal therapy on a group of patients with aggressive periodontitis. Material and Methods: This prospective randomized study included 14 patients with moderate and severe aggressive periodontitis. All patients were treated with nonsurgical periodontal therapy. 170 teeth with at least one baseline probing depth >5 mm were selected for this study. There were 87 teeth treated with nonsurgical periodontal therapy and ACS (test group), and 83 teeth treated with nonsurgical periodontal therapy alone (control group). ACS was generated according to the manufacturer’s instructions, and applied on 5 occasions into designated pockets. Probing depth (PD), gingival recession (RE) and clinical attachment level (CAL) were measured on baseline and after 3 and 6 months. Results: Periodontal treatment, either with or without ACS, led to improvement for all patients except for one. PD and CAL were significantly reduced after 3 and 6 months in both groups (p < 0.001). In comparison with the control group, the test group did not show statistically significant differences in the PD and CAL after 3 and 6 months (p > 0.05). Despite no significance was reported, a trend of lower PD and CAL values was observed in the test group with respect to the control group, especially after 6 months. Conclusion: These results indicate that ACS could be a beneficial adjunct in the treatment of aggressive periodontitis. However, future studies with a larger patient sample and

autologous conditioned serum ; periodontitis ; nonsurgical periodontal therapy

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