engleski

The effect of benzydamine hydrochloride on dental plaque and gingival inflammation

Aim: The aim of the study was to investigate the efficacy of benzydamine hydrochloride solution in preventing de novo development of dental plaque and plaque–induced gingivitis. Material and Methods: This randomized, double- blind study was carried out on 50 systemically and periodontally healthy volunteers, both smokers and non-smokers, divided into two groups. All subjects underwent oral prophylaxis session and were asked not to perform their standard oral hygiene for the next 3 days. During those days, 25 subjects were instructed to rinse with benzydamine hydrochloride solution (test group), while 25 subjects used a placebo mouth rinse (control group). Plaque index (PI) and Bleeding on Probing (BOP) were measured on baseline and after 3 days. Statistical analysis was performed using non- parametric tests. Results: The results of this study showed a significantly lower PI values after 3 days in the test group, as compared with the control (47.9% vs. 73.8%, p < 0.001). Increase in PI values was established across test and control groups, regardless of their smoking status (p < 0.05). The difference in BOP values after 3 days between the test and control group failed to reach statistical significance (p = 0.180). Slightly higher BOP values were found in the test group (13.8% vs. 10.4%) despite lower PI values. No side effects were observed. Conclusion: This study proved the antiseptic properties of benzydamine hydrochloride solution when compared to placebo, but has failed to ascertain its anti- inflammatory effect. Therefore, the use of benzydamine hydrochloride solution as a supplement to regular oral hygiene seems questionable.

oral hygiene ; oral antiseptics ; benzydamine hydrochloride

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