Naslov
Adiponectin response to vegetarian diet is gender- dependent and inversely related to uric acid

Autori
Vučić Lovrenčić, Marijana ; Košuta, Iva ; Gerić, Marko ; Gajski, Goran ; Garaj-Vrhovac, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Endocrine Abstracts ; Vol 37 / - Bratislava : Trnava : BioScientifica, 2015, EP571-EP571

Skup
17th European Congress of Endocrinology 2015

Mjesto i datum
Dublin, Irska, 15.05.2015. - 20.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adiponectin; vegetarian diet; gender; uric acid

Sažetak
Introduction Beneficial influence of vegetarian dietary habits in reducing common risk factors of metabolic syndrome has been recently evidenced. However, adiponectin production and secretion has been scarcely studied in vegetarians, despite it’s important potential in recovering metabolic homeostasis by reducing inflammation and insulin resistance. The aim of this study was to evaluate the influence of vegetarian diet on serum adiponectin levels and it’s association to the established inflammatory and metabolic biomarkers. Methods/design Total serum adiponectin (ADN), leukocytes (L), CRP, plasma glucose (PG), insulin (INS) and uric acid (UA) were measured in healthy, non- obese, age-matched vegetarian (N=40 ; M/F=16/24) and omnivore subjects (N=39 ; M/F=15/24). HOMA-2 model was used for the assessment of beta-cell function (BS), insulin sensitivity (IS) and insulin resistance index (IRI). Results Serum ADN leves were significantly higher in female vegetarians than the respective omnivore controls (14, 2±5, 82 vs. 10, 82±3, 29 mg/L ; P=0, 017), whereas no dietary-associated difference was observed in male vegetarian and omnivore subjects, respectively (6, 87±2, 57 vs. 6, 74±3, 07 mg/L ; P=0, 898). Stepwise multiple regression anaysis identified uric acid as the significant negative determinant of ADN in vegetarians (rpartial=-0, 4585, P=0, 002), while in omnivore subjects only BMI was found to be significantly associated to ADN levels (rpartial=-0, 4439, P=0, 016). In comparison to controls, significantly lower INS (47, 6±19, 2 vs. 57, 7±23, 7 pmol/L ; P=0, 042) and IRI (1, 01±0, 42 vs.1, 22±0, 49 ; P=0, 041), as well as higher BS (115, 5±42, 9 vs. 94, 2±35, 3% ; P=0, 019) were found in vegetarians. Conclusion Vegetarian dietary habits result into improved insulin sensitivity and beta-cell function. Gender diversity in adiponectin response and inverse association to uric acid indicate distinct effects of vegetarian diet to adipose tissue metabolism.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

POVEZANOST RADA