Adiponectin response to vegetarian diet is gender- dependent and inversely related to uric acid (CROSBI ID 625719)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vučić Lovrenčić, Marijana ; Košuta, Iva ; Gerić, Marko ; Gajski, Goran ; Garaj-Vrhovac, Vera
engleski
Adiponectin response to vegetarian diet is gender- dependent and inversely related to uric acid
Introduction Beneficial influence of vegetarian dietary habits in reducing common risk factors of metabolic syndrome has been recently evidenced. However, adiponectin production and secretion has been scarcely studied in vegetarians, despite it’s important potential in recovering metabolic homeostasis by reducing inflammation and insulin resistance. The aim of this study was to evaluate the influence of vegetarian diet on serum adiponectin levels and it’s association to the established inflammatory and metabolic biomarkers. Methods/design Total serum adiponectin (ADN), leukocytes (L), CRP, plasma glucose (PG), insulin (INS) and uric acid (UA) were measured in healthy, non- obese, age-matched vegetarian (N=40 ; M/F=16/24) and omnivore subjects (N=39 ; M/F=15/24). HOMA-2 model was used for the assessment of beta-cell function (BS), insulin sensitivity (IS) and insulin resistance index (IRI). Results Serum ADN leves were significantly higher in female vegetarians than the respective omnivore controls (14, 2±5, 82 vs. 10, 82±3, 29 mg/L ; P=0, 017), whereas no dietary-associated difference was observed in male vegetarian and omnivore subjects, respectively (6, 87±2, 57 vs. 6, 74±3, 07 mg/L ; P=0, 898). Stepwise multiple regression anaysis identified uric acid as the significant negative determinant of ADN in vegetarians (rpartial=-0, 4585, P=0, 002), while in omnivore subjects only BMI was found to be significantly associated to ADN levels (rpartial=-0, 4439, P=0, 016). In comparison to controls, significantly lower INS (47, 6±19, 2 vs. 57, 7±23, 7 pmol/L ; P=0, 042) and IRI (1, 01±0, 42 vs.1, 22±0, 49 ; P=0, 041), as well as higher BS (115, 5±42, 9 vs. 94, 2±35, 3% ; P=0, 019) were found in vegetarians. Conclusion Vegetarian dietary habits result into improved insulin sensitivity and beta-cell function. Gender diversity in adiponectin response and inverse association to uric acid indicate distinct effects of vegetarian diet to adipose tissue metabolism.
adiponectin; vegetarian diet; gender; uric acid
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
EP571-EP571.
2015.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Endocrine abstracts
BioScientifica
1479-6848
Podaci o skupu
17th European Congress of Endocrinology 2015
poster
15.05.2015-20.05.2015
Dublin, Irska