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Pregled bibliografske jedinice broj: 768

Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure


Bogadi-Šare, Ana; Turk, Rajka; Karačić, Višnja; Zavalić, Marija; Trutin-Ostović, Karmen
Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure // Toxicology and industrial health, 13 (1997), 4; 485-494 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 768 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure

Autori
Bogadi-Šare, Ana ; Turk, Rajka ; Karačić, Višnja ; Zavalić, Marija ; Trutin-Ostović, Karmen

Izvornik
Toxicology and industrial health (0748-2337) 13 (1997), 4; 485-494

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzene; hematologic effects; occupational exposure; red blood cell glycerol lysis time

Sažetak
Forty-nine female workers in the shoemaking industry, exposed to a solvent mixture containing benzene and twenty-seven non-exposed controls, were investigated. Concentrations of benzene and toluene in the working atmosphere as well as benzene and toluene in blood and phenols in pre- and post-shift urine as parameters of biological monitoring were determined. In order to assess hematotoxic risk, a complete blood cell count with differential, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, reticulocytes, serum iron, alkaline phosphatase in neutrophils and red blood cell glycerol lysis time were determined in all subjects. Benzene concentrations in the workplace atmosphere at the shoemaking factory ranged from 1.9 to 14.8 ppm (median=5.9). Significant difference in benzene in blood (P=0.005) and phenol in post-shift urine (P=0.003) between exposed workers and controls confirmed exposure to benzene. Hemoglobin level (P=0.02) and mean corpuscular hemoglobin concentration (P=0.0002) in the shoe workers were lower, and band neutrophils (P=0.005) and mean corpuscular volume (P=0.03) higher, than in controls. Red blood cell glycerol lysis time was significantly higher (P=0.000001) in shoe workers (XąSD=41.6ą8.9) than in controls (XąSD=31.2ą6.5) and showed a significant correlation with exposure biomarkers. The results confirm that benzene exposure below 15 ppm may produce qualitative abnormalities, particularly macroerythrocytosis and increased red cell glycerol resistance, in the absence of an overt quantitative decrease in circulating blood cells. Increased resistance to the hemolytic action of glycerol is a potentially useful biological monitoring procedure in medical surveillance of benzene exposed workers. The results of this study suggest that potential threshold concentration for hematologic effects of benzene is lower than 15 ppm.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
00220306

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb


Citiraj ovu publikaciju:

Bogadi-Šare, Ana; Turk, Rajka; Karačić, Višnja; Zavalić, Marija; Trutin-Ostović, Karmen
Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure // Toxicology and industrial health, 13 (1997), 4; 485-494 (međunarodna recenzija, članak, znanstveni)
Bogadi-Šare, A., Turk, R., Karačić, V., Zavalić, M. & Trutin-Ostović, K. (1997) Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure. Toxicology and industrial health, 13 (4), 485-494.
@article{article, year = {1997}, pages = {485-494}, keywords = {benzene, hematologic effects, occupational exposure, red blood cell glycerol lysis time}, journal = {Toxicology and industrial health}, volume = {13}, number = {4}, issn = {0748-2337}, title = {Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure}, keyword = {benzene, hematologic effects, occupational exposure, red blood cell glycerol lysis time} }
@article{article, year = {1997}, pages = {485-494}, keywords = {benzene, hematologic effects, occupational exposure, red blood cell glycerol lysis time}, journal = {Toxicology and industrial health}, volume = {13}, number = {4}, issn = {0748-2337}, title = {Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure}, keyword = {benzene, hematologic effects, occupational exposure, red blood cell glycerol lysis time} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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