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Association of GABA-A receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior


Švob Štrac, Dubravka; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Nenadić Šviglin, Korona; Borovečki, Fran; Pivac, Nela
Association of GABA-A receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior // Progress in neuro-psychopharmacology & biological psychiatry, 63 (2015), 119-125 doi:10.1016/j.pnpbp.2015.06.010 (međunarodna recenzija, članak, znanstveni)


Naslov
Association of GABA-A receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior

Autori
Švob Štrac, Dubravka ; Nedić Erjavec, Gordana ; Nikolac Perković, Matea ; Nenadić Šviglin, Korona ; Borovečki, Fran ; Pivac, Nela

Izvornik
Progress in neuro-psychopharmacology & biological psychiatry (0278-5846) 63 (2015); 119-125

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aggression; alcohol dependence; Cloninger's classification; GABRA2; haplotype; polymorphism

Sažetak
Alcohol dependence is a common chronic disorder precipitated by the complex interaction between biological, genetic and environmental risk factors. Recent studies have demonstrated that polymorphisms of the gene encoding the GABA-A receptor α2 subunit (GABRA2) are associated with alcohol dependence in different populations of European ancestry. As aggression often occurs in the context of alcohol dependence, the aim of this study was to examine the allelic and haplotypic association of GABRA2 gene with alcohol dependence and related aggressive behavior in subjects of Eastern European (Croatian) origin. Genotyping of the 3 single nucleotide polymorphisms (SNPs) across the GABRA2 gene (rs567926, rs279858 and rs9291283) was performed in patients with alcohol dependence (N = 654) and healthy control subjects (N= 574). Alcohol-dependent participants were additionally subdivided according to the presence/absence of aggressive behavior and type of alcohol dependence according to the Cloninger's classification. The association of rs279858 with alcohol dependence yielded nominal significance level. Haplotype analysis revealed a high degree of linkage disequilibrium (LD) for rs567926 and rs279858, but not for rs9291283 polymorphismin the GABRA2 gene. In patientswith alcohol dependence, the A–C (rs567926 and rs279858) haplotype carrierswere more likely to demonstrate aggressive behavior. The samehaplotype (present only in 1.6% of all subjects) was significantly more often present in patients with a combination of early onset alcohol abuse and aggression, corresponding to the Cloninger's type II alcoholism subgroup. These findings support the involvement of GABRA2 gene in alcohol dependence-related aggressive behavior.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0000000-2448 - Stres, GABA-A receptori i mehanizmi djelovanja neuropsihofarmaka (Dubravka Švob Štrac, )
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Nela Pivac, )
108-1081874-1923 - Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima (Fran Borovečki, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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