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Pregled bibliografske jedinice broj: 76682

Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins


Faix, J.; Weber, Igor; Mintert, U.; Köhler J.; Lottspeich; F.; Marriott, G.
Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins // EMBO Journal, 20 (2001), 14; 3705-3715 (međunarodna recenzija, članak, znanstveni)


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Naslov
Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins

Autori
Faix, J. ; Weber, Igor ; Mintert, U. ; Köhler J. ; Lottspeich ; F. ; Marriott, G.

Izvornik
EMBO Journal (0261-4189) 20 (2001), 14; 3705-3715

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Sažetak
Cytokinesis in eukaryotic organisms is under the control of small GTP-binding proteins, although the underlying molecular mechanisms are not fully understood. Cortexillins are actin-binding proteins whose activity is crucial for cytokinesis in Dictyostelium. Here we show that the IQGAP-related and Rac1-binding protein DGAP1 specifically interacts with the C-terminal, actin-bundling domain of cortexillin I. Like cortexillin I, DGAP1 is enriched in the cortex of interphase cells and translocates to the cleavage furrow during cytokinesis. The activated form of the small GTPase Rac1A recruits DGAP1 into a quaternary complex with cortexillin I and II. In DGAP1(-) mutants, a complex can still be formed with a second IQGAP-related protein, GAPA. The simultaneous elimination of DGAP1 and GAPA, however, prevents complex formation and localization of the cortexillins to the cleavage furrow. This leads to a severe defect in cytokinesis, which is similar to that found in cortexillin I/II double-null mutants. Our observations define a novel and functionally significant signaling pathway that is required for cytokinesis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
00981005

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Igor Weber (autor)

Citiraj ovu publikaciju

Faix, J.; Weber, Igor; Mintert, U.; Köhler J.; Lottspeich; F.; Marriott, G.
Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins // EMBO Journal, 20 (2001), 14; 3705-3715 (međunarodna recenzija, članak, znanstveni)
Faix, J., Weber, I., Mintert, U., Köhler J., Lottspeich, F. & Marriott, G. (2001) Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO Journal, 20 (14), 3705-3715.
@article{article, year = {2001}, pages = {3705-3715}, keywords = {}, journal = {EMBO Journal}, volume = {20}, number = {14}, issn = {0261-4189}, title = {Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins}, keyword = {} }
@article{article, year = {2001}, pages = {3705-3715}, keywords = {}, journal = {EMBO Journal}, volume = {20}, number = {14}, issn = {0261-4189}, title = {Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins}, keyword = {} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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