engleski

Evaluation of methyl mercury exposure, susceptibility and health effects in the Mediterranean population

Objective: To investigate methyl mercury (MeHg) exposure, effects, and susceptibility in the Mediterranean population in early life. Methods: PHIME was the largest study ever conducted in the general European population on the impact of mercury through food consumption. It included 1700 mother–child pairs from Italy, Slovenia, Greece and Croatia. Mother’s hair, cord blood, cord tissue and meconium have been sampled at birth, breast milk and mother’s hair 1 month after birth. Hair samples have been analysed for mercury, cord blood and breast milk for mercury (and MeHg), cadmium, lead and arsenic, as well as for essential elements (selenium, zinc, copper). Children were tested for neurodevelopment (Bayley III test) at 18 months of age. In order to observe gene-environment interactions, the glutathione S-transferase class-theta1 (GSTT1) and -mu1 (GSTM1) gene deletion variants were studied in a subset of participating women.

Methyl mercury (MeHg); Exposure; Effects; Susceptibility; Mediterranean

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