engleski

Serum parathormone and nephrogenous cyclic adnenosine monophosphate in stone formers

The date for parathyroid gland activity in stone formers are controversial. Therefore we evaluated parathyroid function gy determining nephrogenous cyclic adenosine 3, 5 - monophosphate (NcAMP) and serum parathyroid hormone (c-terminal) by radioimmunassay in 206 patients with nephrolithiasis and in 70 normal controls. The study was carried out on outpatients basis. Each individual collected a 24-h urine sample on free diet and a 2-h fasting urine sample after 15 hours of fasting. A fasting venous blood sample was taken. The stone formers with daily calcium excretion exceeding 7.5% mmol for males and 6.25 mmol for females were assingned to be hypercalciuric. Eighteen of the 206 patients were diagnosed as having primary hyperparathyroidism (phHPT). Normocalcaemic stone formers (n=188) were placed intio a normacalciuric group (NN, n=128) and a hypercalciuric group (n=60). The hypercalciuric stone formers were further classified according to the criteria reported by Berlin, based on fasting urinary calcium / creatinine molar ratios and renal threshold phosphate concentrations, into hyperabsorbers (AH, n=34) and renal hypercalciuric patients (RH, n=26). The parathyroid function as assessed by mean fasting NcAMP in NN, AH and RH groups as well as in the pHT group was significantly increased as compared with that in the normal controls. However, on the basis of serum i PTH parathyroid activity was estimated to be significatly higher in the pHPT group than in controls and depressed in NN and AH groups.

serum parathormone

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