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Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients


Nadalin, Sergej; Radović, Ivona; Buretić-Tomljanović, Alena
Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients // Prostaglandins leukotrienes and essential fatty acids, 100 (2015), 29-32 doi:10.1016/j.plefa.2015.06.004 (međunarodna recenzija, članak, znanstveni)


Naslov
Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients

Autori
Nadalin, Sergej ; Radović, Ivona ; Buretić-Tomljanović, Alena

Izvornik
Prostaglandins leukotrienes and essential fatty acids (0952-3278) 100 (2015); 29-32

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Niacin skin flush response; PLA2G4C gene polymorphism; PLA2G6 gene polymorphism; schizophrenia.

Sažetak
We hypothesized that attenuated niacin skin flushing in schizophrenia patients might be associated with polymorphic variants in PLA2G6 and PLA2G4C genes (rs4375 and rs1549637 variations) which encode calcium-independent phospholipase A2 beta (iPLA2β) and cytosolic phospholipase A2 gamma (cPLA2γ) enzymes. The iPLA2β and cPLA2γ may play an important role in niacin-mediated signaling ; in addition to their major role – mediating phospholipids remodeling, which alters membrane receptors and signal transduction, they regulate the reservoir of arachidonic acid for prostaglandins synthesis. Skin response to topical niacin of 0.1M, 0.01M, 0.001M and 0.0001M concentrations in 75 schizophrenia patients was rated using the method of volumetric niacin response (VNR). Neither PLA2G6 nor PLA2G4C gene polymorphisms were significantly associated with VNR values. Furthermore, polymorphisms' synergy on niacin skin flushing was also not detected.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
13.06.1.3.39

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Nadalin, Sergej; Radović, Ivona; Buretić-Tomljanović, Alena
Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients // Prostaglandins leukotrienes and essential fatty acids, 100 (2015), 29-32 doi:10.1016/j.plefa.2015.06.004 (međunarodna recenzija, članak, znanstveni)
Nadalin, S., Radović, I. & Buretić-Tomljanović, A. (2015) Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients. Prostaglandins leukotrienes and essential fatty acids, 100, 29-32 doi:10.1016/j.plefa.2015.06.004.
@article{article, year = {2015}, pages = {29-32}, DOI = {10.1016/j.plefa.2015.06.004}, keywords = {niacin skin flush response, PLA2G4C gene polymorphism, PLA2G6 gene polymorphism, schizophrenia.}, journal = {Prostaglandins leukotrienes and essential fatty acids}, doi = {10.1016/j.plefa.2015.06.004}, volume = {100}, issn = {0952-3278}, title = {Polymorphisms in PLA2G6 and PLA2G4C genes for calcium-independent phospholipase A2 do not contribute to attenuated niacin skin flush response in schizophrenia patients}, keyword = {niacin skin flush response, PLA2G4C gene polymorphism, PLA2G6 gene polymorphism, schizophrenia.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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