Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 765077

Biological activity of photochemically generated quinone methides


Basarić, Nikola
Biological activity of photochemically generated quinone methides // IXth Joint Meeting in Medicinal Chemistry
Atena, 2015. (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 765077 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Biological activity of photochemically generated quinone methides

Autori
Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
IXth Joint Meeting in Medicinal Chemistry / - Atena, 2015

Skup
IXth Joint Meeting in Medicinal Chemistry

Mjesto i datum
Atena, Grčka, 7-10.06.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Quinone methides (QM) ; hydoxybiphenyls ; naphthols ; anthracene derivatives ; photochemistry ; photogenerated QMs

Sažetak
Quinone methides (QM) are important reactive intermediates in chemistry of phenols that have attracted scientific attention owing to their biological activity [1]. Some classes of antitumor antibiotics exert their action on metabolic formation of QMs that alkylate DNA molecules. Photochemical reactions of suitably substituted phenols represent particularly applicable method for the QM generation in biological systems since they are conducted under mild conditions and enable spatial and temporal control of the process [2]. Several classes of phenols 1 [3], hydoxybiphenyls 2 [4], naphthols 3 [5] and anthracene derivatives 4, 5 [6], were synthesized and their photochemical reactivity investigated. Antiproliferative activity of the photogenerated QMs was evaluated on three tumor cancer cell lines (colon HCT 116, breast MCF-7, and lung H 460), with and without exposure of cells to UV-vis irradiation. The investigation indicated lead molecules that exhibit enhanced activity on exposure to irradiation. The mechanism of the antiproliferative action was studied for the selected molecules by performing investigation of non-covalent binding to DNA, irradiations of plasmid DNA in the presence of compound, followed by the analysis by alkaline gel electrophoresis, and a study of cell cycle. The experiments indicated that photogenerated QMs do not only react with DNA, but probably inhibit some intracellular enzymes. These findings open new possibilities in the design of compounds for anticancer phototherapy based on photogeneration of QMs.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
grant agreement 316289 InnoMol
FP7-REGPOT-2012-2013-1
HRZZ-IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (SupraPhotoE) (Basarić, Nikola, HRZZ - 2014-09) ( POIROT)
HRZZ-UIP-02.05/25 - Fotokemija policikličkih molekula: od istraživanja mehanizma reakcije do novih lijekova i medicinskih primjena

Profili:

Avatar Url Nikola Basarić (autor)


Citiraj ovu publikaciju

Basarić, Nikola
Biological activity of photochemically generated quinone methides // IXth Joint Meeting in Medicinal Chemistry
Atena, 2015. (predavanje, međunarodna recenzija, sažetak, znanstveni)
Basarić, N. (2015) Biological activity of photochemically generated quinone methides. U: IXth Joint Meeting in Medicinal Chemistry.
@article{article, author = {Basari\'{c}, N.}, year = {2015}, keywords = {Quinone methides (QM), hydoxybiphenyls, naphthols, anthracene derivatives, photochemistry, photogenerated QMs}, title = {Biological activity of photochemically generated quinone methides}, keyword = {Quinone methides (QM), hydoxybiphenyls, naphthols, anthracene derivatives, photochemistry, photogenerated QMs}, publisherplace = {Atena, Gr\v{c}ka} }
@article{article, author = {Basari\'{c}, N.}, year = {2015}, keywords = {Quinone methides (QM), hydoxybiphenyls, naphthols, anthracene derivatives, photochemistry, photogenerated QMs}, title = {Biological activity of photochemically generated quinone methides}, keyword = {Quinone methides (QM), hydoxybiphenyls, naphthols, anthracene derivatives, photochemistry, photogenerated QMs}, publisherplace = {Atena, Gr\v{c}ka} }




Contrast
Increase Font
Decrease Font
Dyslexic Font