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Pregled bibliografske jedinice broj: 764744

UV-induced retinal proteome changes in the rat model of age-related macular degeneration


Kraljević Pavelić, Sandra; Klobučar, Marko; Sedić, Mirela; Micek, Vedran; Gehrig, Peter; Grossman, Jonas; Pavelić, Krešimir; Vojniković, Božidar
UV-induced retinal proteome changes in the rat model of age-related macular degeneration // Biochimica et biophysica acta-molecular basis of disease (2015) (znanstveni, prihvaćen)


Naslov
UV-induced retinal proteome changes in the rat model of age-related macular degeneration

Autori
Kraljević Pavelić, Sandra ; Klobučar, Marko ; Sedić, Mirela ; Micek, Vedran ; Gehrig, Peter ; Grossman, Jonas ; Pavelić, Krešimir ; Vojniković, Božidar

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Biochimica et biophysica acta-molecular basis of disease (2015)

Status rada
Prihvaćen

Ključne riječi
Age-related macular degeneration; UV irradiation; oxidative stress; interphotoreceptor matrix; retinal pigment epithelium; proteomics

Sažetak
Age-related macular degeneration (AMD) is characterized by irreversible damage of photoreceptors in the central posterior part of the retina, called the macula and is the most common cause of vision loss in those aged over 50. A growing body of evidence shows that cumulative long-term exposure to UV radiation may be harmful to the retina and possibly lead to AMD irrespective of age. In spite of many research efforts, cellular and molecular mechanisms leading to UV-induced retinal damage and possibly retinal diseases such as AMD are not completely understood. In the present study we explored damage mechanisms accounting for UV-induced retinal phototoxicity in the rats exposed to UV-A and UV-B irradiation using a proteomics approach. Our study showed that UV irradiation induces profound changes in the retinal proteomes of the rats associated with the disruption of energy homeostasis, oxidative stress, DNA damage response and structural and functional impairment of the interphotoreceptor matrix components and their cell surface receptors such as galectins. Two small leucine-rich proteoglycans, biglycan and lumican, were identified as phototoxicity biomarkers associated with UV-induced disruption of interphotoreceptor matrix (IPM). In addition, UV-B induced activation of Src kinase, which could account for cytoskeletal rearrangements in the retina was observed at the proteomics level. Pharmacological intervention either to target Src kinase with aim of preventing cytoskeletal rearrangements in the retinal pigment epithelium (RPE) and neuronal retina or to help rebuild damaged IPM may provide fresh avenues of treatment for patients suffering from AMD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA


Projekt / tema
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus