engleski

Novel 2-(substituted-phenyl)-6-amino-benzothiazole hydrochlorides : synthesis and antitumor activity

A series of hydrochloride or dihydrochloride salts of the novel 2-(4-substituted-phenyl)-6-amino-benzothiazoles antitumor agents, have been prepared in multistep synthesis starting from substituted benzaldehydes and 3-nitro-substituted o-amino-thiophenol and evaluated on their antitumor activity on following malignant human tumor cell lines : cervical carcinoma (HeLa), breast carcinoma (MCF-7), colon carcinoma (CaCO-2), laryngeal carcinoma (Hep-2), as well as on human fibroblast cell lines (WI-38):

benzothiazoles ; antitumor activity

nije evidentirano