engleski

Acute exhausting exercise session affects microvascular endothelial function in young healthy athletes

Aim: We previously reported impaired microvascular reactivity in athletes after single exposure to exhausting training. The aim of this study was to test if endothelial dysfunction underlies this microvascular impairment. Methods: 9 young trained athletes participated in this study. Blood pressure, heart rate, body mass index (BMI), fasting lipid panel, plasma glucose and C reactive protein (CRP) were measured in all subjects. They all underwent a single progressive rowing training to maximal exhaustion (AE). Blood lactate levels, arterial blood gas analysis and acid base status were measured before and after AE. Cutaneous microvascular blood flow measurements were done by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperemia-PORH) and in response to iontophoresis of acetylcholine (ACh) (endothelium dependent vasodilation) before and after AE. Results: All subjects were normotensive, lean, age- matched males, with normal lipidogram, glucose and CRP blood levels. Serum lactate significantly increased and metabolic acidosis occurred after AE. Systolic blood pressure and heart rate significantly increased during AE. AE caused significant impairment in both microvascular reactivity (PORH) and in ACh induced dilation. Conclusions: The results of this study confirmed that exposure to AE affects microvascular reactivity in young healthy athletes, which is endothelium-dependent.

acute exercise ; microcirculation ; endothelim ; laser Doppler flowmetry

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