Low neural exosomal levels of cellular survival factors inAlzheimer’s disease (CROSBI ID 218344)
Prilog u časopisu | kratko priopćenje
Podaci o odgovornosti
Goetzl, Edward J. ; Boxer, Adam ; Schwartz, Janice B. ; Abner, Erin L. ; Petersen, Ronald C. ; Miller, Bruce L. ; Carlson, Olga D. ; Mustapić, Maja ; Kapogiannis, Dimitrios
engleski
Low neural exosomal levels of cellular survival factors inAlzheimer’s disease
Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1- silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.
exosomes ; Alzheimer's disease ; Frontotemporal dementia ; transcription factors
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
2 (7)
2015.
769-773
objavljeno
2328-9503
10.1002/acn3.211
Povezanost rada
Biologija, Temeljne medicinske znanosti