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izvor podataka: crosbi

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population (CROSBI ID 218153)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Perica, Marija ; Vidović, Mandica ; Lamot, Lovro ; Tambić Bukovac, Lana ; Kapitanović, Sanja ; Perić, Magdalena ; Barbić, Jerko ; Harjaček, Miroslav Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population // Clinical rheumatology, 34 (2015), 12; 2079-2086. doi: 10.1007/s10067-015-2952-8

Podaci o odgovornosti

Perica, Marija ; Vidović, Mandica ; Lamot, Lovro ; Tambić Bukovac, Lana ; Kapitanović, Sanja ; Perić, Magdalena ; Barbić, Jerko ; Harjaček, Miroslav

engleski

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population

Single nucleotide polymorphisms (SNP) of toll-like and NOD-like receptors have been associated with altered receptor activity and modified production of proinflammatory cytokines leading to a number of diseases. Our aim was to determine whether SNP of TLR2 (Arg753Gln), TLR4 (Asp299Gly, Thr399Ile), and NLRP3 (Q705K) influence susceptibility to juvenile spondyloarthrtis (jSpA) and juvenile idiopathic arthritis (JIA). After the DNA extraction, 26 patients with jSpA, 11 with oligoarticular, polyarticular, or systemic JIA, and 40 healthy controls were genotyped for Arg753Gln, Asp299Gly, Thr399Ile, and Q705K SNP using real-time PCR–SNP analysis. Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223). Regarding Asp299Gly SNP, no significant difference in genotype frequency was found ; however, allele frequency was significant in both jSpA and JIA patients. No significant difference in genotype or allele frequency was observed for Arg735Gln and Q705K SNP. The399Ile polymorphism of TLR4 may be responsible for altered immune response to microbial infection in variant carriers and represent a mechanism of triggering overproduction of proinflammatory cytokines and long-term inflammation in jSpA. SNP of TLR2, NLRP3, and TLR4 (Asp299Gly) were not associated with jSpA or JIA.

Juvenile idiopathic arthritis; Juvenile spondyloarthritis; Single nucleotide polymorphism; Toll-like receptor

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

34 (12)

2015.

2079-2086

objavljeno

0770-3198

10.1007/s10067-015-2952-8

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Poveznice
Indeksiranost