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Pregled bibliografske jedinice broj: 760472

Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection


Tomac, Jelena; Juranić Lisnić, Vanda; Bralić, Marina; Krmpotić, Astrid; Dölken, Lars; Jonjić, Stipan
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection // 5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop
Brisbane, Australia, 2015. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection

Autori
Tomac, Jelena ; Juranić Lisnić, Vanda ; Bralić, Marina ; Krmpotić, Astrid ; Dölken, Lars ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop

Mjesto i datum
Brisbane, Australia, 19.-24.04.2015

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; ovary; follicles; corpora lutea

Sažetak
In this study we have used the murine cytomegalovirus (MCMV) model to analyze the impact of cytomegalovirus infection in early pregnancy. We have observed an overwhelming infection of ovarian corpora lutea (CL) which was in a strong contrast to the resistance of ovarian follicles to MCMV infection. The excessive infection of CL granulosa cells, the main producers of progesterone during early pregnancy, was accompanied by a substantial pregnancy loss. Microarray analysis of MCMV infected ovaries revealed a detrimental regulation of key genes involved in the synthesis and degradation of serum progesterone levels as a consequence of virus infection. In addition, we have characterized and discussed the mechanism of differential innate resistance of CL and ovarian follicles to MCMV infection which depends on the cell’s intrinsic antiviral defenses and the immune system.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1265 - Citomegalovirusna infekcija ovarija (Jelena Tomac, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Tomac, Jelena; Juranić Lisnić, Vanda; Bralić, Marina; Krmpotić, Astrid; Dölken, Lars; Jonjić, Stipan
Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection // 5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop
Brisbane, Australia, 2015. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
Tomac, J., Juranić Lisnić, V., Bralić, M., Krmpotić, A., Dölken, L. & Jonjić, S. (2015) Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection. U: 5th International Congenital CMV Conference and 15th International CMV/Betaherpesvirus Workshop.
@article{article, year = {2015}, keywords = {MCMV, ovary, follicles, corpora lutea}, title = {Pathogenesis of cytomegalovirus infection in ovary: Mechanisms of differential resistance of corpora lutea and follicles to infection}, keyword = {MCMV, ovary, follicles, corpora lutea}, publisherplace = {Brisbane, Australia} }