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Pregled bibliografske jedinice broj: 760440

''Cytomegalovirus downregulation of PVR reveals strong effect of DNAM-1 in virus control by NK cells and macrophages''


Jonjić, Stipan; Lenac Roviš, Tihana; Kučan, Paola; Brizić, Ilija; Stanietsky, Noa; Juranić Lisnić, Vanda; Jordan, Stefan; Tomić, Adriana; Babić, Marina; Tsukerman, Pinchas et al.
''Cytomegalovirus downregulation of PVR reveals strong effect of DNAM-1 in virus control by NK cells and macrophages'' // NK2015: 15th Meeting of the Society for Natural Immunity
Fairmont le Chateau Montebello, Quebec, Canada, 2015. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
''Cytomegalovirus downregulation of PVR reveals strong effect of DNAM-1 in virus control by NK cells and macrophages''

Autori
Jonjić, Stipan ; Lenac Roviš, Tihana ; Kučan, Paola ; Brizić, Ilija ; Stanietsky, Noa ; Juranić Lisnić, Vanda ; Jordan, Stefan ; Tomić, Adriana ; Babić, Marina ; Tsukerman, Pinchas ; Messerle, Martin ; Mandelboim, Ofer ; Krmpotić Astrid

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
NK2015: 15th Meeting of the Society for Natural Immunity

Mjesto i datum
Fairmont le Chateau Montebello, Quebec, Canada, 02.-06.05.2015.

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CD155; DNAM1; TIGIT

Sažetak
The poliovirus receptor (PVR), or CD155, is a highly conserved and ubiquitously expressed molecule which plays a role in the immune response to tumours and viruses. PVR serves as a ligand for the activating receptor DNAM-1 as well as for inhibitory receptor TIGIT. PVR also binds to CD96 receptor for which both activating and inhibitory functions have been described. DNAM-1 is expressed on the majority of immune cells including NK cells, monocytes and T lymphocytes and plays a role in the differentiation of memory NK cells. Here we established that mouse cytomegalovirus (MCMV) downregulates the surface expression of PVR and we also characterized the viral protein that retains PVR intracellulary, in spite of an increased transcriptional activity of PVR locus. Since PVR can ligate both inhibitory and activating receptors, the real consequence of PVR downregulation for the immune response is hard to predict. However, MCMV lacking PVR inhibitor was dramatically attenuated in vivo and this attenuated phenotype was only in part due to an augmented virus control by NK cells, while the depletion of macrophages completely abolishes this attenuation. A strong effect of NK cells and macrophages was correlated with a dominant expression of DNAM-1 on these cells upon in vivo infection, while the level of TIGIT receptor was significantly lower. Altogether, our results reveal that DNAM-1 has a physiological significance in virus control by NK cells and macrophages during the early days post infection.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka